CACA [Ligand Id: 4148] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL32307 (Cis-4-Aminocrotonic Acid) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| GABAA receptor ρ1 subunit/GABA receptor rho-1 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3561] [GtoPdb: 420] [UniProtKB: P24046] | ||||||||
| ChEMBL | Partial agonist activity against human rho1 subunit GABA-C receptor expressed in Xenopus oocytes | F | 4.13 | pEC50 | 74000 | nM | EC50 | J Med Chem (2000) 43: 1427-1447 [PMID:10780899] |
| ChEMBL | Agonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method | F | 4.13 | pEC50 | 74000 | nM | EC50 | J Med Chem (2008) 51: 3825-3840 [PMID:18528996] |
| GABAA receptor ρ1 subunit in Rat [GtoPdb: 420] [UniProtKB: P50572] | ||||||||
| GtoPdb | - | - | 4.13 | pEC50 | 74000 | nM | EC50 | Mol Pharmacol (1993) 43: 609-25 [PMID:8386310] |
| GABAA receptor ρ2 subunit/GABA receptor rho-2 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2375] [GtoPdb: 421] [UniProtKB: P28476] | ||||||||
| ChEMBL | Partial agonist activity against human rho-2 subunit GABA-C receptor expressed in Xenopus oocytes | F | 4.15 | pEC50 | 70000 | nM | EC50 | J Med Chem (2000) 43: 1427-1447 [PMID:10780899] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
