flavanone [Ligand Id: 408] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL274318 (NSC-50393) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
| ChEMBL | Binding affinity at Adenosine A1 receptor in rat brain membranes by [3H]PIA displacement. | B | 4.49 | pKi | 32000 | nM | Ki | J Med Chem (1996) 39: 2293-2301 [PMID:8691424] |
| GtoPdb | - | - | 4.5 | pKi | - | - | - | J Med Chem (1996) 39: 2293-301 [PMID:8691424] |
| A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
| GtoPdb | - | - | 4.3 | pKi | - | - | - | J Med Chem (1996) 39: 2293-301 [PMID:8691424] |
| ChEMBL | Binding affinity against human adenosine A3 receptor in HEK293 cells using [125I]AB-MECA 21680 radioligand. | B | 4.3 | pKi | 50100 | nM | Ki | J Med Chem (1996) 39: 2293-2301 [PMID:8691424] |
| Androgen receptor/Androgen Receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275] | ||||||||
| ChEMBL | Antagonist activity at androgen receptor in human MDA-kb2 cells assessed as inhibition of DHT-induced luciferase activity by luciferase reporter gene assay | F | 4.7 | pIC50 | 20000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 4706-4710 [PMID:19592245] |
| Androgen receptor/Androgen Receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207] | ||||||||
| ChEMBL | Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881) | B | 4.26 | pIC50 | 54954.09 | nM | IC50 | J Med Chem (2005) 48: 5666-5674 [PMID:16134935] |
| CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] | ||||||||
| ChEMBL | In vitro inhibition of [1,2,6,7-3H]-androstenedione binding to human placental microsome cytochrome P450 19A1 | B | 4.55 | pIC50 | 28500 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 1059-1061 [PMID:11909717] |
| ChEMBL | Inhibition of human aromatase in placental microsomes | B | 4.55 | pIC50 | 28000 | nM | IC50 | Bioorg Med Chem (2008) 16: 1474-1480 [PMID:18042388] |
| ChEMBL | Inhibition of human aromatase using ASD as substrate pre-incubated for 5 mins followed by substrate addition and measured after 16 hrs by UV/vis-spectrophotometry | B | 4.86 | pIC50 | 13803.84 | nM | IC50 | Eur J Med Chem (2017) 137: 365-438 [PMID:28622580] |
| ChEMBL | Inhibition of aromatase (unknown origin) | B | 5.1 | pIC50 | 8000 | nM | IC50 | Bioorg Med Chem (2014) 22: 126-134 [PMID:24345481] |
| ChEMBL | Inhibition of aromatase (unknown origin) | B | 5.1 | pIC50 | 8000 | nM | IC50 | Eur J Med Chem (2015) 102: 375-386 [PMID:26301554] |
| Monoamine oxidase B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2039] [GtoPdb: 2490] [UniProtKB: P27338] | ||||||||
| ChEMBL | Inhibition of human recombinant MAOB expressed in BTI-TN-5B1-4 cells by para-tyramine oxidation assay | B | 5.54 | pIC50 | 2870 | nM | IC50 | Bioorg Med Chem (2010) 18: 1273-1279 [PMID:20045650] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
