ChEMBL ligand: CHEMBL188528
Estrogen receptor-α/Estrogen receptor alpha in Human [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372] Estrogen receptor-α/Estrogen receptor alpha in Mouse [ChEMBL: CHEMBL3065] [GtoPdb: 620] [UniProtKB: P19785] Estrogen receptor-α/Estrogen receptor alpha in Rat [ChEMBL: CHEMBL2724] [GtoPdb: 620] [UniProtKB: P06211] There should be some charts here, you may need to enable JavaScript!
Estrogen receptor-β/Estrogen receptor beta in Human [ChEMBL: CHEMBL242] [GtoPdb: 621] [UniProtKB: Q92731] Estrogen receptor-β/Estrogen receptor beta in Mouse [ChEMBL: CHEMBL2995] [GtoPdb: 621] [UniProtKB: O08537] Estrogen receptor-β/Estrogen receptor beta in Rat [ChEMBL: CHEMBL3021] [GtoPdb: 621] [UniProtKB: Q62986] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 6/Histone deacetylase 6 in Human [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Estrogen receptor-α/Estrogen receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372]
ChEMBL	Inhibitory concentration against human ER alpha expressed in Escherichia coli was determined using [3H]17-beta-estradiol as radio ligand	B	6.81	pIC50	155	nM	IC50	J Med Chem (2004) 47: 5021-5040 [PMID:15456246]
GtoPdb	-	-	6.81	pEC50	155	nM	EC50	Neuropharmacology (2008) 54: 1136-42 [PMID:18423777]
Estrogen receptor-α/Estrogen receptor alpha in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3065] [GtoPdb: 620] [UniProtKB: P19785]
ChEMBL	Inhibition of [3H]17-beta-estradiol binding to mouse ER alpha expressed in Escherichia coli	B	6.88	pIC50	132	nM	IC50	J Med Chem (2004) 47: 5021-5040 [PMID:15456246]
Estrogen receptor-α/Estrogen receptor alpha in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2724] [GtoPdb: 620] [UniProtKB: P06211]
ChEMBL	Inhibition of [3H]17-beta-estradiol binding to rat ER alpha expressed in Escherichia coli	B	6.88	pIC50	132	nM	IC50	J Med Chem (2004) 47: 5021-5040 [PMID:15456246]
Estrogen receptor-β/Estrogen receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL242] [GtoPdb: 621] [UniProtKB: Q92731]
ChEMBL	Inhibitory concentration against human ER beta expressed in Escherichia coli was determined using [3H]17-beta-estradiol as radio ligand	B	8.7	pIC50	2	nM	IC50	J Med Chem (2004) 47: 5021-5040 [PMID:15456246]
ChEMBL	Binding affinity to ERbeta	B	8.7	pIC50	2	nM	IC50	Eur J Med Chem (2008) 43: 43-52 [PMID:17459530]
ChEMBL	Binding affinity to ERbeta	B	8.85	pIC50	1.4	nM	IC50	Eur J Med Chem (2008) 43: 43-52 [PMID:17459530]
GtoPdb	-	-	9	pIC50	1	nM	IC50	J Med Chem (2004) 47: 5021-40 [PMID:15456246]
GtoPdb	-	-	8.7	pEC50	2	nM	EC50	Neuropharmacology (2008) 54: 1136-42 [PMID:18423777]
Estrogen receptor-β/Estrogen receptor beta in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2995] [GtoPdb: 621] [UniProtKB: O08537]
ChEMBL	Inhibition of [3H]17-beta-estradiol binding to mouse ER beta expressed in Escherichia coli	B	8.77	pIC50	1.7	nM	IC50	J Med Chem (2004) 47: 5021-5040 [PMID:15456246]
Estrogen receptor-β/Estrogen receptor beta in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3021] [GtoPdb: 621] [UniProtKB: Q62986]
ChEMBL	Inhibition of [3H]17-beta-estradiol binding to rat ER beta expressed in Escherichia coli	B	8.92	pIC50	1.2	nM	IC50	J Med Chem (2004) 47: 5021-5040 [PMID:15456246]
histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7]
ChEMBL	Determination of IC50 values for inhibition of enzymatic assay of human HDAC6 with custom peptide substrate	B	6.07	pIC50	854	nM	IC50	HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]