sphingosylphosphorylcholine [Ligand Id: 4032] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1481114 (Sphingosylphosphorylchloline)
  • ADGRF1/Adhesion G-protein coupled receptor F1 in Human [ChEMBL: CHEMBL4523872] [GtoPdb: 190] [UniProtKB: Q5T601]
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  • S1P1 receptor/Sphingosine 1-phosphate receptor Edg-1 in Human [ChEMBL: CHEMBL4333] [GtoPdb: 275] [UniProtKB: P21453]
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  • GPR12 in Human [GtoPdb: 86] [UniProtKB: P47775]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ADGRF1/Adhesion G-protein coupled receptor F1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523872] [GtoPdb: 190] [UniProtKB: Q5T601]
ChEMBL GPCR PRESTO-Tango dose-response in antagonist mode with target: ADGRF1 F 5 pIC50 >10000 nM IC50 EUbOPEN Chemogenomics Library - GPCR Dose-Respose
S1P1 receptor/Sphingosine 1-phosphate receptor Edg-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4333] [GtoPdb: 275] [UniProtKB: P21453]
ChEMBL GPCR PRESTO-Tango dose-response in agonist mode with target: S1PR1 F 6.32 pEC50 483.48 nM EC50 EUbOPEN Chemogenomics Library - GPCR Dose-Respose
GPR12 in Human [GtoPdb: 86] [UniProtKB: P47775]
GtoPdb - - 7.49 pEC50 32 nM EC50 J Neurosci (2003) 23: 907-14 [PMID:12574419]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]