eletriptan [Ligand Id: 40] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1510 (Eletriptan, Relpax, UK-116044, UK-116,044, UK-116044-04, UK-116,044-04 [AS HYDROBROMIDE), UK-116,044-04 FREE BASE, UK-116044-04 FREE BASE)
  • 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
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  • 5-HT1A receptor in Human [GtoPdb: 1] [UniProtKB: P08908]
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  • 5-HT1D receptor in Human [GtoPdb: 3] [UniProtKB: P28221]
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  • 5-ht1e receptor in Human [GtoPdb: 4] [UniProtKB: P28566]
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  • 5-HT1F receptor in Human [GtoPdb: 5] [UniProtKB: P30939]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
GtoPdb - - 8 pKi 10 nM Ki Eur J Pharmacol (1999) 368: 259-68 [PMID:10193663]
ChEMBL Agonist activity at 5-HT1B receptor (unknown origin) F 7.93 pEC50 11.64 nM EC50 Eur J Med Chem (2022) 229: 114045-114045 [PMID:34922191]
5-HT1A receptor in Human [GtoPdb: 1] [UniProtKB: P08908]
GtoPdb - - 7.4 pKi - - - Eur J Pharmacol (1999) 368: 259-68 [PMID:10193663]
5-HT1D receptor in Human [GtoPdb: 3] [UniProtKB: P28221]
GtoPdb - - 8.9 pKi 1.26 nM Ki Eur J Pharmacol (1999) 368: 259-68 [PMID:10193663]
5-ht1e receptor in Human [GtoPdb: 4] [UniProtKB: P28566]
GtoPdb - - 7.2 pKi - - - Eur J Pharmacol (1999) 368: 259-68 [PMID:10193663]
5-HT1F receptor in Human [GtoPdb: 5] [UniProtKB: P30939]
GtoPdb - - 8 pKi 10 nM Ki Eur J Pharmacol (1999) 368: 259-68 [PMID:10193663]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]