ChEMBL ligand: CHEMBL449588 (4-(2-Toluylethynyl)Dihydrocinnamic Acid)
FFA1 receptor/Free fatty acid receptor 1 in Human [ChEMBL: CHEMBL4422] [GtoPdb: 225] [UniProtKB: O14842] There should be some charts here, you may need to enable JavaScript!
FFA4 receptor/G-protein coupled receptor 120 in Human [ChEMBL: CHEMBL5339] [GtoPdb: 127] [UniProtKB: Q5NUL3] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
FFA1 receptor/Free fatty acid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4422] [GtoPdb: 225] [UniProtKB: O14842]
ChEMBL	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	B	6.2	pKi	630.96	nM	Ki	J Med Chem (2016) 59: 4849-4858 [PMID:27074625]
ChEMBL	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	B	7.17	pEC50	67.61	nM	EC50	J Med Chem (2016) 59: 4849-4858 [PMID:27074625]
ChEMBL	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	F	7.34	pEC50	46	nM	EC50	J Med Chem (2013) 56: 982-992 [PMID:23294321]
ChEMBL	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	F	7.34	pEC50	45.71	nM	EC50	J Med Chem (2011) 54: 6691-6703 [PMID:21854074]
ChEMBL	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	F	7.34	pEC50	45.71	nM	EC50	ACS Med Chem Lett (2013) 4: 441-445 [PMID:23687558]
ChEMBL	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	F	7.49	pEC50	32.36	nM	EC50	J Med Chem (2008) 51: 7061-7064 [PMID:18947221]
ChEMBL	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	F	7.49	pEC50	32	nM	EC50	J Med Chem (2008) 51: 7061-7064 [PMID:18947221]
GtoPdb	-	-	7.5	pEC50	-	-	-	J Med Chem (2008) 51: 7061-4 [PMID:18947221]
FFA4 receptor/G-protein coupled receptor 120 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5339] [GtoPdb: 127] [UniProtKB: Q5NUL3]
ChEMBL	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	F	5.65	pEC50	2238.72	nM	EC50	J Med Chem (2012) 55: 4511-4515 [PMID:22519963]
ChEMBL	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	B	5.84	pEC50	1445.44	nM	EC50	ACS Med Chem Lett (2013) 4: 441-445 [PMID:23687558]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]