8-cyclopentyltheophylline [Ligand Id: 385] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL106265 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| A1 receptor in Human [GtoPdb: 18] [UniProtKB: P30542] | ||||||||
| GtoPdb | - | - | 8 | pKi | - | - | - | Biochem Pharmacol (1998) 56: 1437-45 [PMID:9827575] |
| Adenosine A1 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4975] [UniProtKB: P28190] | ||||||||
| ChEMBL | Binding affinity towards adenosine A1 receptor of bovine brain membrane using [3H]-CHA at 20 uM | B | 9.3 | pKi | 0.5 | nM | Ki | J Med Chem (2000) 43: 1158-1164 [PMID:10737748] |
| A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
| ChEMBL | Inhibition of 1 nM [3H]- N6-(phenylisopropyl) adenosine binding to Adenosine A1 receptor in rat cerebral cortical membranes | B | 7.62 | pKi | 24 | nM | Ki | J Med Chem (1989) 32: 1231-1237 [PMID:2724296] |
| ChEMBL | Binding affinity against adenosine A1 receptor using [3H]-CHA or [3H]PIA as radioligand | B | 7.96 | pKi | 11 | nM | Ki | J Med Chem (1992) 35: 407-422 [PMID:1738138] |
| ChEMBL | Inhibition of binding of 1 nM [3H]N-6-(phenylisopropyl)adenosine to adenosine A1 receptor in rat cortical membranes | B | 7.96 | pKi | 10.9 | nM | Ki | J Med Chem (1989) 32: 1873-1879 [PMID:2754711] |
| ChEMBL | Inhibition of [3H]-CHA binding to rat brain membrane Adenosine A1 receptor | B | 9.34 | pKi | 0.46 | nM | Ki | J Med Chem (1990) 33: 3127-3130 [PMID:2258897] |
| Adenosine A1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2304404] [UniProtKB: P47745] | ||||||||
| ChEMBL | Binding affinity against adenosine A1 receptor in guinea pig forebrain membranes using N6-[3H]cyclohexyladenosine as radioligand | B | 7.02 | pKi | 95 | nM | Ki | J Med Chem (1992) 35: 3066-3075 [PMID:1501234] |
| A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
| ChEMBL | Binding affinity towards human adenosine A3 receptor expressed in HEK293 cells using [125I]AB-MECA at 1 uM | B | 5.89 | pKi | 1300 | nM | Ki | J Med Chem (2000) 43: 1158-1164 [PMID:10737748] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
