gallamine [Ligand Id: 356] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL360055 (Gallamine)
  • Acetylcholinesterase in Torpedo californica [ChEMBL: CHEMBL4780] [UniProtKB: P04058]
  • acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
Created with Highcharts 10.3.3ValuesChart context menuAcetylcholinesterasepKd Torpedo californicapKi Torpedo californicapIC50 Torpedo californicapEC50 Torpedo​californicapKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
Created with Highcharts 10.3.3ValuesChart context menuMuscarinic acetylcholine receptor M1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • Muscarinic acetylcholine receptor M2 in Pig [ChEMBL: CHEMBL4781] [UniProtKB: P06199]
Created with Highcharts 10.3.3ValuesChart context menuMuscarinic acetylcholine receptor M2pKd PigpKi PigpIC50 PigpEC50 Pig02468Highcharts.com
  • M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172]
  • M2 receptor in Rat [GtoPdb: 14] [UniProtKB: P10980]
Created with Highcharts 10.3.3ValuesChart context menuM2 receptorpKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd RatpKi RatpIC50 RatpEC50 Rat02468Highcharts.com
  • nicotinic acetylcholine receptor α1 subunit in Human [GtoPdb: 462] [UniProtKB: P02708]
Created with Highcharts 10.3.3ValuesChart context menunicotinic acetylcholine receptor α1 subunitpKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Acetylcholinesterase in Torpedo californica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4780] [UniProtKB: P04058]
ChEMBL Inhibition of Torpedo californica AChE B 4.82 pKi 15000 nM Ki J Med Chem (2008) 51: 3154-3170 [PMID:18479118]
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
ChEMBL Inhibition of human AChE B 4.43 pKi 37000 nM Ki J Med Chem (2008) 51: 3154-3170 [PMID:18479118]
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
ChEMBL Competitive inhibition of EGFP-fused human M1 receptor N-terminal truncated at 17 residues expressed in HEK293 cells after 4 hrs by FRET assay in presence of para-LRB-AC42 B 5.07 pKi 8511.38 nM Ki J Med Chem (2012) 55: 2125-2143 [PMID:22329602]
Muscarinic acetylcholine receptor M2 in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4781] [UniProtKB: P06199]
ChEMBL Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor B 6.88 pEC50 131.83 nM EC50 J Med Chem (2007) 50: 5685-5695 [PMID:17944454]
ChEMBL Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor B 6.89 pEC50 130 nM EC50 J Med Chem (2007) 50: 5685-5695 [PMID:17944454]
M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172]
GtoPdb - - 6.3 pKd - - - Mol Pharmacol (1995) 48: 362-78 [PMID:7651370];
Br J Pharmacol (1976) 58: 323-31 [PMID:990587]
GtoPdb - - 7.6 pKi - - - J Pharmacol Exp Ther (1998) 284: 500-7 [PMID:9454790];
Mol Pharmacol (2003) 64: 180-90 [PMID:12815174];
Mol Pharmacol (2018) 94: 1298-1309 [PMID:30213802]
M2 receptor in Rat [GtoPdb: 14] [UniProtKB: P10980]
GtoPdb - - 5.6 pKi - - - J Pharmacol Exp Ther (1998) 284: 500-7 [PMID:9454790]
nicotinic acetylcholine receptor α1 subunit in Human [GtoPdb: 462] [UniProtKB: P02708]
GtoPdb - - 6 pIC50 ~1000 nM IC50

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]