YIL781 [Ligand Id: 3538] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL243001 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ghrelin receptor/Ghrelin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4616] [GtoPdb: 246] [UniProtKB: Q92847] | ||||||||
| GtoPdb | - | - | 7.77 | pKi | 17 | nM | Ki | Endocrinology (2007) 148: 5175-85 [PMID:17656463] |
| ChEMBL | Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting | B | 8.4 | pKi | 4 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 2271-2278 [PMID:22342626] |
| Ghrelin receptor in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5015] [UniProtKB: Q8MHZ5] | ||||||||
| ChEMBL | Displacement of [125I]ghrelin from ovine recombinant GHSR1a expressed in HEK293F cells after 6 hrs by scintillation proximity assay | B | 7.77 | pKi | 17 | nM | Ki | J Med Chem (2007) 50: 5202-5216 [PMID:17887659] |
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human Erg by patch clamp assay | B | 5.79 | pIC50 | 1621.81 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 2271-2278 [PMID:22342626] |
| ChEMBL | Inhibition of human Erg by patch clamp assay | B | 5.8 | pIC50 | 1600 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 2271-2278 [PMID:22342626] |
| 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
| ChEMBL | Displacement of [125I]DIO from 5HT2c receptor | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2007) 50: 5202-5216 [PMID:17887659] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
