LY262691 [Ligand Id: 3509] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL333081 (LY-288513) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CCK1 receptor/Cholecystokinin A receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551] | ||||||||
| ChEMBL | Half maximal inhibition of specific binding of [125I]-Bolton-Hunter CCK-8 to Cholecystokinin type A receptor in the rat pancreas | B | 4.69 | pIC50 | 20500 | nM | IC50 | J Med Chem (2000) 43: 3505-3517 [PMID:11000005] |
| ChEMBL | The compound was tested for its activity to inhibit the binding of [3H]-L-364,718 to Cholecystokinin type A receptor in rat pancreas | B | 4.69 | pIC50 | 20500 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 875-880 |
| CCK2 receptor/Cholecystokinin B receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2854] [GtoPdb: 77] [UniProtKB: P56481] | ||||||||
| ChEMBL | Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex | B | 7.72 | pIC50 | 19 | nM | IC50 | J Med Chem (2000) 43: 3505-3517 [PMID:11000005] |
| ChEMBL | The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5 | B | 7.72 | pIC50 | 19 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 875-880 |
| CCK2 receptor in Rat [GtoPdb: 77] [UniProtKB: P30553] | ||||||||
| GtoPdb | - | - | 7.5 | pIC50 | 31 | nM | IC50 | Nature (2011) 469: 175-80 [PMID:21228869] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
