L-168,049 [Ligand Id: 3505] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL351772 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| glucagon receptor/Glucagon receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1985] [GtoPdb: 251] [UniProtKB: P47871] | ||||||||
| ChEMBL | Antagonist activity at human glucagon receptor | B | 5.84 | pIC50 | 1442.12 | nM | IC50 | Med Chem Res (2013) null: 1-16 |
| ChEMBL | Binding affinity towards glucagon receptor determined by reduction in binding of [125I]glucagon to the human glucagon receptor (GGR) expressed on CHO cells in presence of Mg+2 | B | 6.77 | pIC50 | 170 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 641-646 [PMID:10201821] |
| ChEMBL | Binding affinity determined by reduction in binding of 125 I-glucagon to the human glucagon receptor expressed on CHO cells in absence of Mg+2 | B | 8.15 | pIC50 | 7 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 641-646 [PMID:10201821] |
| GtoPdb | - | - | 8.4 | pIC50 | 3.7 | nM | IC50 | J Biol Chem (1999) 274: 8694-7 [PMID:10085108] |
| glucagon receptor/Glucagon receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4773] [GtoPdb: 251] [UniProtKB: Q61606] | ||||||||
| ChEMBL | Binding affinity towards glucagon receptor determined by reduction in binding of 125 I-glucagon to the murine glucagon receptor (mGLUR) expressed on CHO cells in presence of Mg+2 | B | 6.6 | pIC50 | 250 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 641-646 [PMID:10201821] |
| ChEMBL | Binding affinity towards glucagon receptor determined by reduction in binding of [125I]glucagon to the murine glucagon receptor (GGR) expressed on CHO cells in absence of Mg+2 | B | 7.43 | pIC50 | 37 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 641-646 [PMID:10201821] |
| mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
| ChEMBL | Inhibitory activity against p38-alpha kinase | B | 5.84 | pIC50 | 1440 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 641-646 [PMID:10201821] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
