ChEMBL ligand: CHEMBL296641 (Antalarmin)
CRF1 receptor/Corticotropin releasing factor receptor 1 in Human [ChEMBL: CHEMBL1800] [GtoPdb: 212] [UniProtKB: P34998] CRF1 receptor/Corticotropin releasing factor receptor 1 in Rat [ChEMBL: CHEMBL4649] [GtoPdb: 212] [UniProtKB: P35353] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CRF1 receptor/Corticotropin releasing factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1800] [GtoPdb: 212] [UniProtKB: P34998]
ChEMBL	Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells by cAMP assay	F	7.49	pKi	32	nM	Ki	Bioorg Med Chem Lett (2012) 22: 723-728 [PMID:22104142]
ChEMBL	Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cells	B	8.51	pKi	3.1	nM	Ki	J Med Chem (2005) 48: 5104-5107 [PMID:16078829]
ChEMBL	Inhibition of [125I]sauvagine binding to corticotropin releasing factor receptor 1 expressed in LtK- cells	B	8.51	pKi	3.1	nM	Ki	J Med Chem (2005) 48: 4100-4110 [PMID:15943483]
ChEMBL	Binding affinity for human corticotropin releasing factor receptor 1 expressed in LtK- cells using [125I]sauvagine	B	8.6	pKi	2.51	nM	Ki	J Med Chem (2005) 48: 5780-5793 [PMID:16134945]
GtoPdb	-	-	9	pKi	1	nM	Ki	Endocrinology (1996) 137: 5747-50 [PMID:8940412]
ChEMBL	Binding affinity to recombinant human Corticotropin releasing factor receptor 1 (hCRF1) expressed in 293EBNA cells	B	9.08	pKi	0.84	nM	Ki	J Med Chem (1999) 42: 833-848 [PMID:10072681]
ChEMBL	Displacement of [125I]Tyr0sauvagine from human CRF1 receptor expressed in HEK293 cell membrane after 120 mins by gamma scintillation counting analysis	B	7.73	pIC50	18.62	nM	IC50	Eur J Med Chem (2014) 78: 1-9 [PMID:24675175]
ChEMBL	Displacement of [125I]-Tyr0-sauvagine from human CRFR1 expressed in HEK293 cell membrane homogenates after 120 mins by gamma counting method	B	7.73	pIC50	18.62	nM	IC50	Eur J Med Chem (2017) 138: 900-908 [PMID:28750312]
CRF1 receptor/Corticotropin releasing factor receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4649] [GtoPdb: 212] [UniProtKB: P35353]
ChEMBL	Compound was tested in vitro for its ability to displace [125 I]Tyr-sauvagine from corticotropin-releasing hormone type 1 receptor in rat cerebellum	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem Lett (2000) 10: 707-710 [PMID:10782669]
ChEMBL	Affinity for the Corticotropin releasing factor receptor 1 (CRHR1) was determined in rat brain	B	9	pKi	1	nM	Ki	J Med Chem (2003) 46: 3559-3562 [PMID:12904058]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]