12S-HETE [Ligand Id: 3404] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1526258 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| OXE receptor/Oxoeicosanoid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1628461] [GtoPdb: 271] [UniProtKB: Q8TDS5] | ||||||||
| ChEMBL | Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition by fluorescence assay | F | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2018) 61: 5934-5948 [PMID:29972644] |
| GPR31 in Mouse [GtoPdb: 98] [UniProtKB: F8VQN3] | ||||||||
| GtoPdb | - | - | 9.55 | pEC50 | 0.28 | nM | EC50 | J Biol Chem (2011) 286: 33832-40 [PMID:21712392] |
| BLT2 receptor in Human [GtoPdb: 268] [UniProtKB: Q9NPC1] | ||||||||
| GtoPdb | - | - | 7.52 | pEC50 | >30 | nM | EC50 | J Biol Chem (2001) 276: 12454-9 [PMID:11278893] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
