5-oxo-ETE [Ligand Id: 3391] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL18028 (5-Oxo-ETE) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 12S-LOX/Arachidonate 12-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3687] [GtoPdb: 1387] [UniProtKB: P18054] | ||||||||
| ChEMBL | Inhibition of human platelet 12-lipoxygenase by UV-visible spectrophotometry | B | 4.82 | pIC50 | 15000 | nM | IC50 | Bioorg Med Chem (2014) 22: 4293-4297 [PMID:24924423] |
| 15-LOX-1/Arachidonate 15-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2903] [GtoPdb: 1388] [UniProtKB: P16050] | ||||||||
| ChEMBL | Inhibition of human reticulocyte 15-lipoxygenase-1 by UV-visible spectrophotometry | B | 4.6 | pIC50 | >25000 | nM | IC50 | Bioorg Med Chem (2014) 22: 4293-4297 [PMID:24924423] |
| Arachidonate 15-lipoxygenase in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4358] [UniProtKB: P12530] | ||||||||
| ChEMBL | Inhibition of rabbit reticulocyte 15-LOX by UV-visible spectrophotometry | B | 4.6 | pIC50 | >25000 | nM | IC50 | Bioorg Med Chem (2014) 22: 4293-4297 [PMID:24924423] |
| 15-LOX-2/Arachidonate 15-lipoxygenase, type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2457] [GtoPdb: 1389] [UniProtKB: O15296] | ||||||||
| ChEMBL | Inhibition of human reticulocyte 15-lipoxygenase-2 by UV-visible spectrophotometry | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem (2014) 22: 4293-4297 [PMID:24924423] |
| 5-LOX/Arachidonate 5-lipoxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527] | ||||||||
| ChEMBL | In vitro inhibitory activity against 5-lipoxygenase from rat basophilic leukemia cells. | B | 4.74 | pIC50 | 18000 | nM | IC50 | J Med Chem (1987) 30: 1177-1186 [PMID:3599023] |
| OXE receptor/Oxoeicosanoid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1628461] [GtoPdb: 271] [UniProtKB: Q8TDS5] | ||||||||
| ChEMBL | Desensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization | F | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 1987-1990 [PMID:21377873] |
| ChEMBL | Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay | F | 6.66 | pEC50 | 220 | nM | EC50 | Bioorg Med Chem (2018) 26: 3580-3587 [PMID:29866479] |
| ChEMBL | Agonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assay | F | 7.17 | pEC50 | 67 | nM | EC50 | Medchemcomm (2012) 3: 195-198 |
| ChEMBL | Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization | F | 8.15 | pEC50 | 7 | nM | EC50 | Bioorg Med Chem Lett (2011) 21: 1857-1860 [PMID:21316960] |
| GtoPdb | - | - | 8.5 | pEC50 | 3.1 | nM | EC50 |
J Biol Chem (1995) 270: 15029-36 [PMID:7797484]; Prostaglandins Other Lipid Mediat (2009) 89: 98-104 [PMID:19450703]; J Pharmacol Exp Ther (2008) 325: 698-707 [PMID:18292294]; J Biol Chem (1998) 273: 32535-41 [PMID:9829988]; J Biol Chem (1992) 267: 19233-41 [PMID:1326548] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
