VPC23019 [Ligand Id: 3324] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL228102
  • S1P1 receptor/Sphingosine 1-phosphate receptor Edg-1 in Human [ChEMBL: CHEMBL4333] [GtoPdb: 275] [UniProtKB: P21453]
Created with Highcharts 10.3.3ValuesChart context menuSphingosine 1-phosphate receptor Edg-1pKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • S1P3 receptor/Sphingosine 1-phosphate receptor Edg-3 in Human [ChEMBL: CHEMBL3892] [GtoPdb: 277] [UniProtKB: Q99500]
Created with Highcharts 10.3.3ValuesChart context menuSphingosine 1-phosphate receptor Edg-3pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • S1P4 receptor/Sphingosine 1-phosphate receptor Edg-6 in Human [ChEMBL: CHEMBL3230] [GtoPdb: 278] [UniProtKB: O95977]
Created with Highcharts 10.3.3ValuesChart context menuSphingosine 1-phosphate receptor Edg-6pKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
  • S1P5 receptor/Sphingosine 1-phosphate receptor Edg-8 in Human [ChEMBL: CHEMBL2274] [GtoPdb: 279] [UniProtKB: Q9H228]
Created with Highcharts 10.3.3ValuesChart context menuSphingosine 1-phosphate receptor Edg-8pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
S1P1 receptor/Sphingosine 1-phosphate receptor Edg-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4333] [GtoPdb: 275] [UniProtKB: P21453]
GtoPdb - - 7.86 pKi - - - J Biol Chem (2005) 280: 9833-41 [PMID:15590668]
ChEMBL Activity at human S1P1 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay F 7.24 pEC50 58 nM EC50 Bioorg Med Chem (2007) 15: 663-677 [PMID:17113298]
S1P3 receptor/Sphingosine 1-phosphate receptor Edg-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3892] [GtoPdb: 277] [UniProtKB: Q99500]
GtoPdb - - 5.93 pKi - - - J Biol Chem (2005) 280: 9833-41 [PMID:15590668]
ChEMBL Activity at human S1P3 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay F 6.35 pEC50 450 nM EC50 Bioorg Med Chem (2007) 15: 663-677 [PMID:17113298]
S1P4 receptor/Sphingosine 1-phosphate receptor Edg-6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3230] [GtoPdb: 278] [UniProtKB: O95977]
ChEMBL Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay F 6.3 pEC50 500 nM EC50 Bioorg Med Chem (2007) 15: 663-677 [PMID:17113298]
S1P5 receptor/Sphingosine 1-phosphate receptor Edg-8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2274] [GtoPdb: 279] [UniProtKB: Q9H228]
ChEMBL Activity at human S1P5 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay F 7.28 pEC50 52 nM EC50 Bioorg Med Chem (2007) 15: 663-677 [PMID:17113298]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]