methoctramine [Ligand Id: 327] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL27673 (Methoctramine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
| ChEMBL | Inhibition of acetylcholinesterase (AChE) of human erythrocytes | B | 5.27 | pIC50 | 5370.32 | nM | IC50 | J Med Chem (1998) 41: 4186-4189 [PMID:9784091] |
| ChEMBL | Inhibitory concentration against acetylcholinesterase from human erythrocytes | B | 5.27 | pIC50 | 5370.32 | nM | IC50 | J Med Chem (2003) 46: 954-966 [PMID:12620072] |
| ChEMBL | Inhibitory activity on Acetylcholinesterase (AChE) from human erythrocytes | B | 5.27 | pIC50 | 5370.32 | nM | IC50 | J Med Chem (2002) 45: 3286-3295 [PMID:12109912] |
| butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] | ||||||||
| ChEMBL | Inhibition of Butyrylcholinesterase (BChE) of human erythrocytes [-log IC50 (uM)] | B | 6.01 | pIC50 | 977.24 | nM | IC50 | J Med Chem (1998) 41: 4186-4189 [PMID:9784091] |
| ChEMBL | Inhibitory concentration against butyrylcholinesterase from human serum | B | 6.01 | pIC50 | 977.24 | nM | IC50 | J Med Chem (2003) 46: 954-966 [PMID:12620072] |
| GluN1/GluN2A/Glutamate NMDA receptor; GRIN1/GRIN2A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907604] [GtoPdb: 455, 456] [UniProtKB: Q05586, Q12879] | ||||||||
| ChEMBL | Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-induced inward current at -70mV by two-electrode voltage clamp assay | B | 6.86 | pIC50 | 138 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3901-3904 [PMID:23692871] |
| M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229] | ||||||||
| ChEMBL | Antagonistic potency against Muscarinic acetylcholine receptor M1 (10 uM) | F | 6.85 | pKd | 141.25 | nM | Kd | J Med Chem (1998) 41: 4186-4189 [PMID:9784091] |
| ChEMBL | Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M1 expressed in CHO cells | B | 7.08 | pKi | 83.18 | nM | Ki | Bioorg Med Chem (2007) 15: 2312-2321 [PMID:17276075] |
| GtoPdb | - | - | 7.3 | pKi | - | - | - |
Biochem Pharmacol (1996) 52: 643-58 [PMID:8759038]; J Recept Signal Transduct Res (1997) 17: 177-84 [PMID:9029489]; J Pharmacol Exp Ther (1991) 256: 727-33 [PMID:1994002]; Br J Pharmacol (1997) 120: 1409-18 [PMID:9113359] |
| ChEMBL | Affinity for human M1 cloned muscarinic receptor subtype expressed in CHO-K1 cells | B | 7.3 | pKi | 49.8 | nM | Ki | J Med Chem (2001) 44: 4035-4038 [PMID:11708906] |
| M1 receptor/Muscarinic acetylcholine receptor M1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL276] [GtoPdb: 13] [UniProtKB: P08482] | ||||||||
| ChEMBL | Binding affinity for rat cortex Muscarinic acetylcholine receptor M1 | B | 7.38 | pKi | 41.69 | nM | Ki | J Med Chem (1998) 41: 4150-4160 [PMID:9767650] |
| ChEMBL | Affinity constant measured against M1 muscarinic receptor in rat cortex | B | 7.43 | pKi | 37.15 | nM | Ki | J Med Chem (1993) 36: 3734-3737 [PMID:8246244] |
| ChEMBL | Tested for affinity constant against M1 muscarinic receptor in rat cortex using [3H]pirenzepine | B | 7.43 | pKi | 37.15 | nM | Ki | J Med Chem (1994) 37: 3363-3372 [PMID:7932564] |
| ChEMBL | Inhibition of binding of [3H]pirenzepine to muscarinic receptor (M1) in rat cortex homogenates | B | 7.43 | pKi | 37.15 | nM | Ki | Bioorg Med Chem Lett (1995) 5: 785-790 |
| GtoPdb | - | - | 7.8 | pKi | - | - | - | Mol Pharmacol (1989) 35: 469-76 [PMID:2704370] |
| M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172] | ||||||||
| ChEMBL | Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor | F | 7.71 | pKd | 19.5 | nM | Kd | J Med Chem (1989) 32: 79-84 [PMID:2909747] |
| ChEMBL | Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor) | F | 7.82 | pKd | 15.14 | nM | Kd | J Med Chem (1993) 36: 3734-3737 [PMID:8246244] |
| ChEMBL | Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist] | F | 7.82 | pKd | 15.14 | nM | Kd | J Med Chem (1994) 37: 3363-3372 [PMID:7932564] |
| ChEMBL | Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium | F | 7.91 | pKd | 12.3 | nM | Kd | J Med Chem (1998) 41: 4150-4160 [PMID:9767650] |
| ChEMBL | Antagonistic potency against Muscarinic acetylcholine receptor M2 | F | 7.92 | pKd | 12.02 | nM | Kd | J Med Chem (1998) 41: 4186-4189 [PMID:9784091] |
| ChEMBL | Displacement of radiolabeled methoctramine from human muscarinic M2 receptor | B | 7.44 | pKi | 36 | nM | Ki | J Med Chem (2008) 51: 7094-7098 [PMID:18983139] |
| ChEMBL | Displacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cells | B | 7.57 | pKi | 27 | nM | Ki | J Med Chem (2014) 57: 4543-4557 [PMID:24805037] |
| ChEMBL | Binding affinity to human muscarinic M2 receptor by radioligand displacement assay | B | 7.59 | pKi | 26 | nM | Ki | Eur J Med Chem (2013) 63: 85-94 [PMID:23466604] |
| ChEMBL | Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells | B | 7.84 | pKi | 14.3 | nM | Ki | J Med Chem (2001) 44: 4035-4038 [PMID:11708906] |
| GtoPdb | - | - | 8.4 | pKi | - | - | - |
Biochem Pharmacol (1996) 52: 643-58 [PMID:8759038]; Mol Pharmacol (1989) 35: 469-76 [PMID:2704370]; J Pharmacol Exp Ther (1998) 284: 500-7 [PMID:9454790]; J Pharmacol Exp Ther (2006) 316: 279-88 [PMID:16188951]; J Pharmacol Exp Ther (1991) 256: 727-33 [PMID:1994002]; Br J Pharmacol (1997) 120: 1409-18 [PMID:9113359] |
| ChEMBL | Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cells | B | 8.62 | pKi | 2.4 | nM | Ki | Bioorg Med Chem (2007) 15: 2312-2321 [PMID:17276075] |
| ChEMBL | Displacement of radiolabeled methoctramine from human muscarinic M2 receptor | B | 7.29 | pIC50 | 51 | nM | IC50 | J Med Chem (2008) 51: 7094-7098 [PMID:18983139] |
| ChEMBL | Binding affinity to human muscarinic M2 receptor by radioligand displacement assay | B | 7.43 | pIC50 | 37 | nM | IC50 | Eur J Med Chem (2013) 63: 85-94 [PMID:23466604] |
| ChEMBL | Percent inhibition against Muscarinic acetylcholine receptor M2 at 1 uM | B | 7.47 | pIC50 | 34 | nM | IC50 | J Med Chem (2005) 48: 6887-6896 [PMID:16250647] |
| Muscarinic acetylcholine receptor M2 in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4781] [UniProtKB: P06199] | ||||||||
| ChEMBL | Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart | B | 5.52 | pEC50 | 2999.16 | nM | EC50 | J Med Chem (2003) 46: 1390-1407 [PMID:12672239] |
| M2 receptor/Muscarinic acetylcholine receptor M2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL309] [GtoPdb: 14] [UniProtKB: P10980] | ||||||||
| GtoPdb | - | - | 7.3 | pKi | - | - | - | J Pharmacol Exp Ther (1998) 284: 500-7 [PMID:9454790] |
| ChEMBL | Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2 | B | 7.7 | pKi | 19.95 | nM | Ki | J Med Chem (1998) 41: 4150-4160 [PMID:9767650] |
| ChEMBL | Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart | B | 7.82 | pKi | 15 | nM | Ki | J Med Chem (1998) 41: 1557-1560 [PMID:9572880] |
| ChEMBL | Affinity constant measured against M2 muscarinic receptor in rat heart | B | 7.84 | pKi | 14.45 | nM | Ki | J Med Chem (1993) 36: 3734-3737 [PMID:8246244] |
| ChEMBL | Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS | B | 7.84 | pKi | 14.45 | nM | Ki | J Med Chem (1994) 37: 3363-3372 [PMID:7932564] |
| ChEMBL | Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates | B | 7.84 | pKi | 14.45 | nM | Ki | Bioorg Med Chem Lett (1995) 5: 785-790 |
| M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309] | ||||||||
| ChEMBL | Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M3 expressed in CHO cells | B | 6.28 | pKi | 524.81 | nM | Ki | Bioorg Med Chem (2007) 15: 2312-2321 [PMID:17276075] |
| ChEMBL | Affinity for human M3 cloned muscarinic receptor subtype expressed in CHO-K1 cells | B | 6.56 | pKi | 277 | nM | Ki | J Med Chem (2001) 44: 4035-4038 [PMID:11708906] |
| GtoPdb | - | - | 6.9 | pKi | - | - | - |
Biochem Pharmacol (1996) 52: 643-58 [PMID:8759038]; Mol Pharmacol (1989) 35: 469-76 [PMID:2704370]; J Recept Signal Transduct Res (1997) 17: 177-84 [PMID:9029489]; J Pharmacol Exp Ther (1991) 256: 727-33 [PMID:1994002]; Br J Pharmacol (1997) 120: 1409-18 [PMID:9113359] |
| M3 receptor/Muscarinic acetylcholine receptor M3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL320] [GtoPdb: 15] [UniProtKB: P08483] | ||||||||
| ChEMBL | Affinity constant measured against M3 muscarinic receptor in rat submaxillary gland | B | 5.96 | pKi | 1096.48 | nM | Ki | J Med Chem (1993) 36: 3734-3737 [PMID:8246244] |
| ChEMBL | Tested for affinity constant against M3 muscarinic receptor in rat submaxillary gland using [3H]NMS | B | 5.96 | pKi | 1096.48 | nM | Ki | J Med Chem (1994) 37: 3363-3372 [PMID:7932564] |
| ChEMBL | Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M3) in rat submaxillary gland homogenates | B | 5.96 | pKi | 1096.48 | nM | Ki | Bioorg Med Chem Lett (1995) 5: 785-790 |
| ChEMBL | Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M3 using [3H]NMS from rat submaxillary gland | B | 6 | pKi | 998 | nM | Ki | J Med Chem (1998) 41: 1557-1560 [PMID:9572880] |
| ChEMBL | Inhibition of [3H]NMS binding to rat submaxillary gland Muscarinic acetylcholine receptor M3 | B | 6.02 | pKi | 954.99 | nM | Ki | J Med Chem (1998) 41: 4150-4160 [PMID:9767650] |
| Muscarinic acetylcholine receptor M3 in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5498] [UniProtKB: Q8VH26] | ||||||||
| ChEMBL | Antagonistic potency against Muscarinic acetylcholine receptor M3 (10 uM) | F | 6.06 | pKd | 870.96 | nM | Kd | J Med Chem (1998) 41: 4186-4189 [PMID:9784091] |
| ChEMBL | Antagonist potency against carbachol induced contractions of isolated guinea pig ileum Muscarinic acetylcholine receptor | F | 6.08 | pKd | 831.76 | nM | Kd | J Med Chem (1989) 32: 79-84 [PMID:2909747] |
| ChEMBL | Antagonistic activity measured in isolated guinea pig left ileum (M3 receptor) | F | 6.32 | pKd | 478.63 | nM | Kd | J Med Chem (1993) 36: 3734-3737 [PMID:8246244] |
| ChEMBL | Antagonistic activity against M3 muscarinic receptor in guinea pig left ileum derived by plotting log(DR - 1) vs log[antagonist] | F | 6.32 | pKd | 478.63 | nM | Kd | J Med Chem (1994) 37: 3363-3372 [PMID:7932564] |
| ChEMBL | Antagonist affinity evaluated against Muscarinic acetylcholine receptor M3 in isolated guinea pig longitudinal Ileum. | F | 6.44 | pKd | 363.08 | nM | Kd | J Med Chem (1998) 41: 4150-4160 [PMID:9767650] |
| M4 receptor/Muscarinic acetylcholine receptor M4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173] | ||||||||
| ChEMBL | Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M4 expressed in CHO cells | B | 6.97 | pKi | 107.15 | nM | Ki | Bioorg Med Chem (2007) 15: 2312-2321 [PMID:17276075] |
| ChEMBL | Affinity for human M4 cloned muscarinic receptor subtype expressed in CHO-K1 cells | B | 7.42 | pKi | 38 | nM | Ki | J Med Chem (2001) 44: 4035-4038 [PMID:11708906] |
| GtoPdb | - | - | 7.5 | pKi | - | - | - |
Biochem Pharmacol (1996) 52: 643-58 [PMID:8759038]; Mol Pharmacol (1989) 35: 469-76 [PMID:2704370]; J Pharmacol Exp Ther (1991) 256: 727-33 [PMID:1994002]; Br J Pharmacol (1997) 120: 1409-18 [PMID:9113359] |
| M4 receptor/Muscarinic acetylcholine receptor M4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL317] [GtoPdb: 16] [UniProtKB: P08485] | ||||||||
| ChEMBL | Inhibition of NG 108-15 binding to Muscarinic acetylcholine receptor M4 | B | 7.49 | pKi | 32.36 | nM | Ki | J Med Chem (1998) 41: 4150-4160 [PMID:9767650] |
| ChEMBL | Affinity constant measured against M4 muscarinic receptor rat NG108-15 cells | B | 7.58 | pKi | 26.3 | nM | Ki | J Med Chem (1993) 36: 3734-3737 [PMID:8246244] |
| ChEMBL | Inhibition of binding of [3H]N-methylscopolamine to Muscarinic acetylcholine receptor M4 in NG 108-15 cell homogenates | B | 7.58 | pKi | 26.3 | nM | Ki | Bioorg Med Chem Lett (1995) 5: 785-790 |
| M5 receptor/Muscarinic acetylcholine receptor M5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912] | ||||||||
| ChEMBL | Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M5 expressed in CHO cells | B | 6.26 | pKi | 549.54 | nM | Ki | Bioorg Med Chem (2007) 15: 2312-2321 [PMID:17276075] |
| ChEMBL | Affinity for human muscarinic acetylcholine receptor M5 subtype expressed in CHO-K1 cells | B | 6.5 | pKi | 313 | nM | Ki | J Med Chem (2001) 44: 4035-4038 [PMID:11708906] |
| GtoPdb | - | - | 7.2 | pKi | - | - | - |
Biochem Pharmacol (1996) 52: 643-58 [PMID:8759038]; Mol Pharmacol (1989) 35: 469-76 [PMID:2704370]; J Pharmacol Exp Ther (1991) 256: 727-33 [PMID:1994002]; Br J Pharmacol (1997) 120: 1409-18 [PMID:9113359] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
