ChEMBL ligand: CHEMBL392760 (WAY-181187)
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] There should be some charts here, you may need to enable JavaScript!
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] There should be some charts here, you may need to enable JavaScript!
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406] There should be some charts here, you may need to enable JavaScript!
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
ChEMBL	Inhibition of human 5HT2B receptor expressed in CHO cells	B	6.34	pKi	458	nM	Ki	J Med Chem (2007) 50: 5535-5538 [PMID:17948978]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
ChEMBL	Inhibition of human 5HT2C receptor expressed in CHO cells	B	6.91	pKi	124	nM	Ki	J Med Chem (2007) 50: 5535-5538 [PMID:17948978]
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
ChEMBL	Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constant	B	8.66	pKi	2.2	nM	Ki	Bioorg Med Chem Lett (2021) 49: 128275-128275 [PMID:34311086]
ChEMBL	Displacement of [3H]-LSD from human 5-HT6 receptor expressed in human HeLa cells assessed as inhibition constant incubated for 120 mins by Topcount scintillation counting analysis	B	8.66	pKi	2.2	nM	Ki	J Med Chem (2024) 67: 1580-1610 [PMID:38190615]
ChEMBL	Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells	B	8.7	pKi	2	nM	Ki	J Med Chem (2009) 52: 6153-6157 [PMID:19739674]
ChEMBL	Displacement of [3H]LSD from human 5HT6 receptor expressed in HeLa cells	B	8.7	pKi	2	nM	Ki	J Med Chem (2007) 50: 5535-5538 [PMID:17948978]
ChEMBL	Displacement of [3H]lysergic acid diethylamide from human 5-HT6 receptor expressed in HeLa cells after 120 mins by scintillation counter	B	8.7	pKi	2	nM	Ki	J Med Chem (2015) 58: 7901-7912 [PMID:26099069]
ChEMBL	Binding affinity to 5HT6 receptor	B	8.7	pKi	2	nM	Ki	Bioorg Med Chem (2009) 17: 7387-7397 [PMID:19758807]
ChEMBL	Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells by liquid scintillation counting	B	8.7	pKi	2	nM	Ki	J Med Chem (2009) 52: 675-687 [PMID:19159187]
GtoPdb	-	-	8.7	pKi	-	-	-	Neuropsychopharmacology (2008) 33: 1323-35 [PMID:17625499]
ChEMBL	Agonist activity at human 5HT6 receptor expressed in HeLa cells assessed as cAMP production	F	8.19	pEC50	6.5	nM	EC50	J Med Chem (2007) 50: 5535-5538 [PMID:17948978]
ChEMBL	Agonist activity at human 5HT6 receptor expressed in HeLa cells assessed as induction of cAMP production after 10 mins by radioimmunoassay	F	8.19	pEC50	6.5	nM	EC50	J Med Chem (2009) 52: 6153-6157 [PMID:19739674]
ChEMBL	Agonist activity at 5HT6 receptor	F	8.19	pEC50	6.5	nM	EC50	Bioorg Med Chem (2009) 17: 7387-7397 [PMID:19758807]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
ChEMBL	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	B	6.17	pKi	679	nM	Ki	J Med Chem (2007) 50: 5535-5538 [PMID:17948978]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]