WAY-181187 [Ligand Id: 3240] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL392760 (WAY-181187) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] | ||||||||
| ChEMBL | Inhibition of human 5HT2B receptor expressed in CHO cells | B | 6.34 | pKi | 458 | nM | Ki | J Med Chem (2007) 50: 5535-5538 [PMID:17948978] |
| 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
| ChEMBL | Inhibition of human 5HT2C receptor expressed in CHO cells | B | 6.91 | pKi | 124 | nM | Ki | J Med Chem (2007) 50: 5535-5538 [PMID:17948978] |
| 5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406] | ||||||||
| ChEMBL | Displacement of [3H]LSD from human 5HT6 receptor expressed in HeLa cells | B | 8.7 | pKi | 2 | nM | Ki | J Med Chem (2007) 50: 5535-5538 [PMID:17948978] |
| ChEMBL | Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells by liquid scintillation counting | B | 8.7 | pKi | 2 | nM | Ki | J Med Chem (2009) 52: 675-687 [PMID:19159187] |
| ChEMBL | Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells | B | 8.7 | pKi | 2 | nM | Ki | J Med Chem (2009) 52: 6153-6157 [PMID:19739674] |
| ChEMBL | Binding affinity to 5HT6 receptor | B | 8.7 | pKi | 2 | nM | Ki | Bioorg Med Chem (2009) 17: 7387-7397 [PMID:19758807] |
| ChEMBL | Displacement of [3H]lysergic acid diethylamide from human 5-HT6 receptor expressed in HeLa cells after 120 mins by scintillation counter | B | 8.7 | pKi | 2 | nM | Ki | J Med Chem (2015) 58: 7901-7912 [PMID:26099069] |
| GtoPdb | - | - | 8.7 | pKi | - | - | - | Neuropsychopharmacology (2008) 33: 1323-35 [PMID:17625499] |
| ChEMBL | Agonist activity at human 5HT6 receptor expressed in HeLa cells assessed as cAMP production | F | 8.19 | pEC50 | 6.5 | nM | EC50 | J Med Chem (2007) 50: 5535-5538 [PMID:17948978] |
| ChEMBL | Agonist activity at human 5HT6 receptor expressed in HeLa cells assessed as induction of cAMP production after 10 mins by radioimmunoassay | F | 8.19 | pEC50 | 6.5 | nM | EC50 | J Med Chem (2009) 52: 6153-6157 [PMID:19739674] |
| ChEMBL | Agonist activity at 5HT6 receptor | F | 8.19 | pEC50 | 6.5 | nM | EC50 | Bioorg Med Chem (2009) 17: 7387-7397 [PMID:19758807] |
| 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969] | ||||||||
| ChEMBL | Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells | B | 6.17 | pKi | 679 | nM | Ki | J Med Chem (2007) 50: 5535-5538 [PMID:17948978] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
