compound 11 [PMID: 18800762] [Ligand Id: 3191] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL416301
  • farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324]
Created with Highcharts 10.3.3ValuesChart context menuFarnesyl diphosphate synthasepKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
  • Farnesyl pyrophosphate synthase in Leishmania donovani [ChEMBL: CHEMBL3693] [UniProtKB: Q0GKD7]
Created with Highcharts 10.3.3ValuesChart context menuFarnesyl pyrophosphate synthasepKd Leishmania donovanipKi Leishmania donovanipIC50 Leishmania donovanipEC50 Leishmania donovani0123456Highcharts.com
  • geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749]
Created with Highcharts 10.3.3ValuesChart context menuGeranylgeranyl pyrophosphate synthetasepKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuPlasmodium falciparumpKd Plasmodium falciparumpKi Plasmodium falciparumpIC50 Plasmodium falciparumpEC50 Plasmodium falciparum01234567Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324]
ChEMBL Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligand B 6.13 pKi 740 nM Ki J Med Chem (2003) 46: 5171-5183 [PMID:14613320]
ChEMBL Inhibitory activity against farnesyl Pyrophosphate Synthase was determined B 5.11 pIC50 7800 nM IC50 J Med Chem (2003) 46: 5171-5183 [PMID:14613320]
ChEMBL Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME? (M) B 5.11 pIC50 7762.47 nM IC50 J Med Chem (2003) 46: 5171-5183 [PMID:14613320]
Farnesyl pyrophosphate synthase in Leishmania donovani (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3693] [UniProtKB: Q0GKD7]
ChEMBL Inhibitory activity against Leishmania major Farnesyl diphosphate synthase B 5.11 pIC50 7750 nM IC50 J Med Chem (2004) 47: 175-187 [PMID:14695831]
geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749]
ChEMBL Inhibition of human recombinant geranylgeranyl diphosphate synthase B 5.57 pIC50 2690 nM IC50 J Med Chem (2008) 51: 5594-5607 [PMID:18800762]
ChEMBL Inhibition of human recombinant geranylgeranyl diphosphate synthase B 5.6 pIC50 2511.89 nM IC50 J Med Chem (2008) 51: 5594-5607 [PMID:18800762]
GtoPdb Inhibition of human recombinant geranylgeranyl diphosphate synthase - 5.6 pIC50 - - - J Med Chem (2008) 51: 5594-607 [PMID:18800762]
ChEMBL Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase). B 6.04 pIC50 920 nM IC50 J Med Chem (2002) 45: 2185-2196 [PMID:12014956]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL In vitro growth inhibition against Plasmodium falciparum F 5.97 pIC50 1070 nM IC50 J Med Chem (2004) 47: 175-187 [PMID:14695831]
ChEMBL Antiparasitic activity against Plasmodium falciparum 3D7 infected in human erythrocyte assessed as intraerythrocytic growth inhibition incubated for 24 hrs followed by [3H]hypoxanthine addition by microbeta scintillation counter analysis F 5.97 pIC50 1070 nM IC50 J Med Chem (2021) 64: 1260-1282 [PMID:33522236]
ChEMBL Antimicrobial activity against Plasmodium falciparum F 6 pIC50 1000 nM IC50 Bioorg Med Chem (2010) 18: 2225-2231 [PMID:20185316]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]