ChEMBL ligand: CHEMBL258994 (Digeranyl Bisphosphonate)
farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324] There should be some charts here, you may need to enable JavaScript!
geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324]
ChEMBL	Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 mins prior to substrate addition measured after 10 mins by scintillation counting	B	5	pIC50	>10000	nM	IC50	J Med Chem (2012) 55: 3201-3215 [PMID:22390415]
ChEMBL	Inhibition of human FPPS	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem (2013) 21: 2229-2240 [PMID:23477945]
geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749]
GtoPdb	Inhibition of human recombinant geranylgeranyl diphosphate synthase	-	6	pIC50	-	-	-	J Med Chem (2008) 51: 5594-607 [PMID:18800762]
ChEMBL	Inhibition of human recombinant geranylgeranyl diphosphate synthase	B	6	pIC50	1000	nM	IC50	J Med Chem (2008) 51: 5594-5607 [PMID:18800762]
ChEMBL	Inhibition of human recombinant geranylgeranyl diphosphate synthase	B	6.01	pIC50	980	nM	IC50	J Med Chem (2008) 51: 5594-5607 [PMID:18800762]
ChEMBL	Inhibition of human N-terminal His6-tagged GGPPS Y246D mutant expressed in Escherichia coli BL21(DE3) using [14C]-IPP and FPP as substrates after 10 mins by scintillation counting	B	6.23	pIC50	590	nM	IC50	J Med Chem (2018) 61: 6904-6917 [PMID:30016091]
ChEMBL	Inhibition of human N-terminal His6-tagged GGPPS expressed in Escherichia coli BL21(DE3) using [14C]-IPP and FPP as substrates after 10 mins by scintillation counting	B	6.37	pIC50	430	nM	IC50	J Med Chem (2018) 61: 6904-6917 [PMID:30016091]
ChEMBL	Inhibition of human recombinant N-terminal His6 tagged GGPPS expressed in Escherichia coli BL21 using FPP and [14C]IPP as substrate incubated for 10 mins prior to substrate addition by scintillation counting	B	6.39	pIC50	410	nM	IC50	J Med Chem (2012) 55: 3201-3215 [PMID:22390415]
ChEMBL	Inhibition of recombinant GGDPS (unknown origin) assessed as decrease in radiolabeld GGPP level using FPP and [14C]IPP as substrate treated with enzyme for 10 mins prior to substrate challenge for 30 mins by liquid scintillation counting analysis	B	6.7	pIC50	200	nM	IC50	Bioorg Med Chem (2014) 22: 2791-2798 [PMID:24726306]
ChEMBL	Inhibition of GST-tagged human recombinant GGDPS expressed in BL21 gold bacteria	B	6.7	pIC50	200	nM	IC50	Bioorg Med Chem (2008) 16: 390-399 [PMID:17905588]
ChEMBL	Inhibition of human recombinant GGDPS expressed in BL21 gold bacteria	B	6.7	pIC50	200	nM	IC50	Bioorg Med Chem (2008) 16: 3652-3660 [PMID:18308574]
GtoPdb	recombinant human protein expressed in BL21 gold bacteria, purified, in vitro assay	-	6.7	pIC50	200	nM	IC50	Biochem Biophys Res Commun (2007) 353: 921-5 [PMID:17208200]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]