[3H]QNB [Ligand Id: 318] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL12980
  • Muscarinic acetylcholine receptor DM1 in Drosophila melanogaster [ChEMBL: CHEMBL2366467] [UniProtKB: P16395]
There should be some charts here, you may need to enable JavaScript!
  • M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
  • Muscarinic acetylcholine receptor M1 in Bovine [ChEMBL: CHEMBL2672] [UniProtKB: Q8WMX0]
There should be some charts here, you may need to enable JavaScript!
  • M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
  • M2 receptor/Muscarinic acetylcholine receptor M2 in Rat [ChEMBL: CHEMBL309] [GtoPdb: 14] [UniProtKB: P10980]
There should be some charts here, you may need to enable JavaScript!
  • Muscarinic acetylcholine receptor M3 in Guinea pig [ChEMBL: CHEMBL5498] [UniProtKB: Q8VH26]
There should be some charts here, you may need to enable JavaScript!
  • Vesicular acetylcholine transporter in Rat [ChEMBL: CHEMBL2125] [GtoPdb: 1013] [UniProtKB: Q62666]
There should be some charts here, you may need to enable JavaScript!
  • M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
There should be some charts here, you may need to enable JavaScript!
  • M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
There should be some charts here, you may need to enable JavaScript!
  • M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Muscarinic acetylcholine receptor DM1 in Drosophila melanogaster (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366467] [UniProtKB: P16395]
ChEMBL Displacement of [3H]QNB from Drosophila melanogaster mAChR by scintillation counting B 9.3 pKi 0.5 nM Ki J Agric Food Chem (2007) 55: 2276-2281 [PMID:17319687]
ChEMBL Displacement of [3H]AF-DX 384 from Drosophila melanogaster mAChR by scintillation counting B 9.3 pKi 0.5 nM Ki J Agric Food Chem (2007) 55: 2276-2281 [PMID:17319687]
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
GtoPdb - - 10.8 pKd 0.02 nM Kd EMBO J (1987) 6: 3923-9 [PMID:3443095];
J Pharmacol Exp Ther (1995) 274: 1077-83 [PMID:7562472]
ChEMBL Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]QNB from guinea pig cerebral cortex B 10.29 pKi 0.05 nM Ki J Med Chem (1995) 38: 473-487 [PMID:7853341]
Muscarinic acetylcholine receptor M1 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2672] [UniProtKB: Q8WMX0]
ChEMBL In vitro binding affinity against bovine striatal membrane using [3H]pirenzepine B 9.66 pKi 0.22 nM Ki J Med Chem (1995) 38: 1711-1719 [PMID:7752195]
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
GtoPdb - - 10.6 pKd 0.03 nM Kd EMBO J (1987) 6: 3923-9 [PMID:3443095];
J Pharmacol Exp Ther (1995) 274: 1077-83 [PMID:7562472]
ChEMBL Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart B 10.35 pKi 0.04 nM Ki J Med Chem (1995) 38: 473-487 [PMID:7853341]
M2 receptor/Muscarinic acetylcholine receptor M2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL309] [GtoPdb: 14] [UniProtKB: P10980]
ChEMBL In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384 B 9.74 pKi 0.18 nM Ki J Med Chem (1995) 38: 1711-1719 [PMID:7752195]
Muscarinic acetylcholine receptor M3 in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5498] [UniProtKB: Q8VH26]
ChEMBL In vitro binding affinity against guinea pig ileum using [3H]N-methylscopolamine B 8.33 pKi 4.63 nM Ki J Med Chem (1995) 38: 1711-1719 [PMID:7752195]
ChEMBL Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]QNB from guinea pig parotid gland B 9.62 pKi 0.24 nM Ki J Med Chem (1995) 38: 473-487 [PMID:7853341]
Vesicular acetylcholine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2125] [GtoPdb: 1013] [UniProtKB: Q62666]
ChEMBL Displacement of [125I]O-iodo-trans-decalinvesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 1 hr by gamma counting B 6.24 pKi 581.7 nM Ki Bioorg Med Chem (2012) 20: 4936-4941 [PMID:22831799]
M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
GtoPdb - - 10.4 pKd 0.04 nM Kd EMBO J (1987) 6: 3923-9 [PMID:3443095];
J Pharmacol Exp Ther (1995) 274: 1077-83 [PMID:7562472]
M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
GtoPdb - - 10.5 pKd 0.03 nM Kd Nature (1988) 334: 434-7 [PMID:2841607];
J Pharmacol Exp Ther (1995) 274: 1077-83 [PMID:7562472]
M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912]
GtoPdb - - 10.7 pKd 0.02 nM Kd J Pharmacol Exp Ther (1995) 274: 1077-83 [PMID:7562472]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]