[3H]QNB [Ligand Id: 318] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL12980
  • Muscarinic acetylcholine receptor DM1 in Drosophila melanogaster [ChEMBL: CHEMBL2366467] [UniProtKB: P16395]
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  • M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
  • Muscarinic acetylcholine receptor M1 in Bovine [ChEMBL: CHEMBL2672] [UniProtKB: Q8WMX0]
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  • M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
  • M2 receptor/Muscarinic acetylcholine receptor M2 in Rat [ChEMBL: CHEMBL309] [GtoPdb: 14] [UniProtKB: P10980]
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  • Muscarinic acetylcholine receptor M3 in Guinea pig [ChEMBL: CHEMBL5498] [UniProtKB: Q8VH26]
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  • Vesicular acetylcholine transporter in Rat [ChEMBL: CHEMBL2125] [GtoPdb: 1013] [UniProtKB: Q62666]
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  • M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
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  • M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
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  • M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Muscarinic acetylcholine receptor DM1 in Drosophila melanogaster (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366467] [UniProtKB: P16395]
ChEMBL Displacement of [3H]QNB from Drosophila melanogaster mAChR by scintillation counting B 9.3 pKi 0.5 nM Ki J Agric Food Chem (2007) 55: 2276-2281 [PMID:17319687]
ChEMBL Displacement of [3H]AF-DX 384 from Drosophila melanogaster mAChR by scintillation counting B 9.3 pKi 0.5 nM Ki J Agric Food Chem (2007) 55: 2276-2281 [PMID:17319687]
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
GtoPdb - - 10.8 pKd 0.02 nM Kd EMBO J (1987) 6: 3923-9 [PMID:3443095];
J Pharmacol Exp Ther (1995) 274: 1077-83 [PMID:7562472]
ChEMBL Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]QNB from guinea pig cerebral cortex B 10.29 pKi 0.05 nM Ki J. Med. Chem. (1995) 38: 473-487 [PMID:7853341]
Muscarinic acetylcholine receptor M1 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2672] [UniProtKB: Q8WMX0]
ChEMBL In vitro binding affinity against bovine striatal membrane using [3H]pirenzepine B 9.66 pKi 0.22 nM Ki J. Med. Chem. (1995) 38: 1711-1719 [PMID:7752195]
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
GtoPdb - - 10.6 pKd 0.03 nM Kd EMBO J (1987) 6: 3923-9 [PMID:3443095];
J Pharmacol Exp Ther (1995) 274: 1077-83 [PMID:7562472]
ChEMBL Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart B 10.35 pKi 0.04 nM Ki J. Med. Chem. (1995) 38: 473-487 [PMID:7853341]
M2 receptor/Muscarinic acetylcholine receptor M2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL309] [GtoPdb: 14] [UniProtKB: P10980]
ChEMBL In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384 B 9.74 pKi 0.18 nM Ki J. Med. Chem. (1995) 38: 1711-1719 [PMID:7752195]
Muscarinic acetylcholine receptor M3 in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5498] [UniProtKB: Q8VH26]
ChEMBL In vitro binding affinity against guinea pig ileum using [3H]N-methylscopolamine B 8.33 pKi 4.63 nM Ki J. Med. Chem. (1995) 38: 1711-1719 [PMID:7752195]
ChEMBL Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]QNB from guinea pig parotid gland B 9.62 pKi 0.24 nM Ki J. Med. Chem. (1995) 38: 473-487 [PMID:7853341]
Vesicular acetylcholine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2125] [GtoPdb: 1013] [UniProtKB: Q62666]
ChEMBL Displacement of [125I]O-iodo-trans-decalinvesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 1 hr by gamma counting B 6.24 pKi 581.7 nM Ki Bioorg. Med. Chem. (2012) 20: 4936-4941 [PMID:22831799]
M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
GtoPdb - - 10.4 pKd 0.04 nM Kd EMBO J (1987) 6: 3923-9 [PMID:3443095];
J Pharmacol Exp Ther (1995) 274: 1077-83 [PMID:7562472]
M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
GtoPdb - - 10.5 pKd 0.03 nM Kd Nature (1988) 334: 434-7 [PMID:2841607];
J Pharmacol Exp Ther (1995) 274: 1077-83 [PMID:7562472]
M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912]
GtoPdb - - 10.7 pKd 0.02 nM Kd J Pharmacol Exp Ther (1995) 274: 1077-83 [PMID:7562472]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]