zoledronic acid [Ligand Id: 3177] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL924 (CGP-42446, Reclast, Zometa) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| farnesyl diphosphate synthase in Human [GtoPdb: 644] [UniProtKB: P14324] | ||||||||
| GtoPdb | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins | - | 7.07 | pKi | 85.9 | nM | Ki | J Med Chem (2008) 51: 2187-95 [PMID:18327899] |
| GtoPdb | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins | - | 10.15 | pKi | 0.07 | nM | Ki | J Med Chem (2008) 51: 2187-95 [PMID:18327899] |
| GtoPdb | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins | - | 6.32 | pIC50 | 475.3 | nM | IC50 | J Med Chem (2008) 51: 2187-95 [PMID:18327899] |
| GtoPdb | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins | - | 8.39 | pIC50 | 4.1 | nM | IC50 | J Med Chem (2008) 51: 2187-95 [PMID:18327899] |
| GtoPdb | Inhibition of human FPP synthase expressed in Escherichia coli BL21 (DE3) | - | 8.39 | pIC50 | 4.1 | nM | IC50 | J Med Chem (2008) 51: 6800-7 [PMID:18937434] |
| farnesyl diphosphate synthase in Rat [GtoPdb: 644] [UniProtKB: P05369] | ||||||||
| GtoPdb | in vitro using kidney cell lines | - | 6.3 | pIC50 | 500 | nM | IC50 | Toxicol In Vitro (2008) 22: 899-909 [PMID:18325729] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
