ChEMBL ligand: CHEMBL923 (Actonel, M05BA07, NE-58095, Ridron, Risedronate, Risedronic acid)
butyrophilin subfamily 3 member A1/Butyrophilin subfamily 3 member A1 in Human [ChEMBL: CHEMBL4105758] [GtoPdb: 2948] [UniProtKB: O00481] There should be some charts here, you may need to enable JavaScript!
Farnesyl diphosphate synthase in Trypanosoma cruzi [ChEMBL: CHEMBL4752] [UniProtKB: Q8WS26] Farnesyl diphosphate synthase in Toxoplasma gondii [ChEMBL: CHEMBL5831] [UniProtKB: Q197X6] farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324] There should be some charts here, you may need to enable JavaScript!
Farnesyl pyrophosphate synthase in Leishmania donovani [ChEMBL: CHEMBL3693] [UniProtKB: Q0GKD7] Farnesyl pyrophosphate synthase in Leishmania major [ChEMBL: CHEMBL2150832] [UniProtKB: Q4QBL1] There should be some charts here, you may need to enable JavaScript!
geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749] There should be some charts here, you may need to enable JavaScript!
Plasmodium berghei [ChEMBL: CHEMBL612653] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
butyrophilin subfamily 3 member A1/Butyrophilin subfamily 3 member A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105758] [GtoPdb: 2948] [UniProtKB: O00481]
ChEMBL	Binding affinity to BTN3A1 in human PBMC-derived Vgamma9/Vdelta2 T cells	B	7.1	pEC50	80	nM	EC50	J Med Chem (2020) 63: 11258-11270 [PMID:32930595]
Farnesyl diphosphate synthase in Trypanosoma cruzi (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4752] [UniProtKB: Q8WS26]
ChEMBL	Inhibition of Trypanosoma cruzi FPPS after 30 mins using [14C]IPP by scintillation counting	B	7.57	pIC50	27	nM	IC50	Bioorg Med Chem (2011) 19: 2211-2217 [PMID:21419634]
ChEMBL	Inhibition of Trypanosoma cruzi farnesyl diphosphate synthase assessed as incorporation of [4-14C]IPP measured at 37 degC	B	7.57	pIC50	27	nM	IC50	Eur J Med Chem (2013) 60: 431-440 [PMID:23318904]
Farnesyl diphosphate synthase in Toxoplasma gondii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5831] [UniProtKB: Q197X6]
ChEMBL	Inhibition of Toxoplasma gondii FPPS after 30 mins using [14C]IPP by scintillation counting	B	7.13	pIC50	74	nM	IC50	Bioorg Med Chem (2011) 19: 2211-2217 [PMID:21419634]
ChEMBL	Inhibition of Toxoplasma gondii farnesyl diphosphate synthase assessed as incorporation of [4-14C]IPP measured at 37 degC	B	7.13	pIC50	74	nM	IC50	Eur J Med Chem (2013) 60: 431-440 [PMID:23318904]
ChEMBL	Inhibition of Toxoplasma gondii recombinant FPPS expressed in Escherichia coli using [4-14C]IPP/DMAPP/GPP as substrate after 30 mins by scintillation counting analysis	B	7.13	pIC50	74	nM	IC50	Bioorg Med Chem (2014) 22: 398-405 [PMID:24300918]
farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324]
ChEMBL	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21	B	7.09	pKi	82.2	nM	Ki	J Med Chem (2008) 51: 2187-2195 [PMID:18327899]
GtoPdb	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins	-	7.09	pKi	82.2	nM	Ki	J Med Chem (2008) 51: 2187-95 [PMID:18327899]
ChEMBL	Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligand	B	7.8	pKi	16	nM	Ki	J Med Chem (2003) 46: 5171-5183 [PMID:14613320]
GtoPdb	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins	-	9.44	pKi	0.36	nM	Ki	J Med Chem (2008) 51: 2187-95 [PMID:18327899]
ChEMBL	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins	B	9.44	pKi	0.36	nM	Ki	J Med Chem (2008) 51: 2187-2195 [PMID:18327899]
ChEMBL	Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [3H]IPP and GPP as substrate measured after 20 mins by liquid scintillation counting	B	6.07	pIC50	860	nM	IC50	J Med Chem (2012) 55: 3201-3215 [PMID:22390415]
GtoPdb	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins	-	6.34	pIC50	452.9	nM	IC50	J Med Chem (2008) 51: 2187-95 [PMID:18327899]
ChEMBL	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21	B	6.34	pIC50	452.9	nM	IC50	J Med Chem (2008) 51: 2187-2195 [PMID:18327899]
ChEMBL	Inhibition of N-terminal His-tagged human FPPS expressed in Escherichia coli	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem Lett (2010) 20: 5781-5786 [PMID:20801032]
ChEMBL	Inhibitory activity against farnesyl Pyrophosphate Synthase was determined	B	6.77	pIC50	170	nM	IC50	J Med Chem (2003) 46: 5171-5183 [PMID:14613320]
ChEMBL	Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME? (M)	B	6.77	pIC50	169.82	nM	IC50	J Med Chem (2003) 46: 5171-5183 [PMID:14613320]
ChEMBL	Inhibition of human FPPS in absence of pre-incubation of compound with enzyme	B	7.09	pIC50	82	nM	IC50	ACS Med Chem Lett (2015) 6: 349-354 [PMID:25815158]
ChEMBL	Inhibition of recombinant human C-terminal His6-tagged FPPS expressed in Escherichia coli BL21 using DMAPP and IPP as substrates pretreated for 15 mins followed by substrates addition and measured after 1 hr by colorimetric method	B	7.15	pIC50	70	nM	IC50	Eur J Med Chem (2018) 158: 184-200 [PMID:30216851]
ChEMBL	Inhibition of human FPPS	B	7.96	pIC50	11	nM	IC50	Bioorg Med Chem Lett (2015) 25: 1117-1123 [PMID:25630225]
ChEMBL	Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 mins prior to substrate addition measured after 10 mins by scintillation counting	B	7.96	pIC50	11	nM	IC50	J Med Chem (2012) 55: 3201-3215 [PMID:22390415]
ChEMBL	Inhibition of human His6-tagged recombinant FPPS expressed in Escherichia coli BL21(DE3) using GPP and [3H]IPP as substrate incubated for 5 mins prior to substrate addition measured after 20 mins by liquid scintillation counting	B	7.96	pIC50	11	nM	IC50	Bioorg Med Chem (2012) 20: 5583-5591 [PMID:22884353]
ChEMBL	Inhibition of human recombinant FPPS using GPP/[3H]IPP as substrate incubated for 10 mins prior to substrate addition by scintillation counting analysis	B	7.96	pIC50	11	nM	IC50	J Med Chem (2013) 56: 7939-7950 [PMID:23998921]
GtoPdb	In vitro inhibition of recombinant human FDPS expressed in E.coli.	-	8	pIC50	10	nM	IC50	J Pharmacol Exp Ther (2001) 296: 235-42 [PMID:11160603]
ChEMBL	Inhibition of FDPS (unknown origin)	B	8	pIC50	10	nM	IC50	Bioorg Med Chem Lett (2019) 29: 126757-126757 [PMID:31699606]
ChEMBL	Inhibition of recombinant human FPPS expressed in Escherichia coli by scintillation counting	B	8	pIC50	10	nM	IC50	J Med Chem (2011) 54: 5955-5980 [PMID:21780776]
ChEMBL	Inhibitory activity against the human recombinant FPPSase (Farnesyl diphosphate) enzyme	B	8	pIC50	10	nM	IC50	J Med Chem (2002) 45: 2185-2196 [PMID:12014956]
ChEMBL	Inhibition of FDPS (unknown origin)	B	8.22	pIC50	6	nM	IC50	Bioorg Med Chem Lett (2015) 25: 2331-2334 [PMID:25935643]
ChEMBL	Allosteric inhibition of human recombinant FPPS using GPP and [3H]IPP as substrate incubated with enzyme for 10 mins prior to substrate addition by liquid scintillation counting analysis	B	8.22	pIC50	6	nM	IC50	J Med Chem (2014) 57: 5764-5776 [PMID:24911527]
GtoPdb	in vitro assay, inhibition of recombinant human enzyme expressed in E.coli	-	8.24	pIC50	5.7	nM	IC50	J Pharmacol Exp Ther (2001) 296: 235-42 [PMID:11160603]
GtoPdb	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins	-	8.24	pIC50	5.7	nM	IC50	J Med Chem (2008) 51: 2187-95 [PMID:18327899]
ChEMBL	Inhibition of human FPPS	B	8.24	pIC50	5.7	nM	IC50	Bioorg Med Chem Lett (2008) 18: 2878-2882 [PMID:18434151]
ChEMBL	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins	B	8.24	pIC50	5.7	nM	IC50	J Med Chem (2008) 51: 2187-2195 [PMID:18327899]
ChEMBL	Inhibition of human recombinant FPPS using GPP/[3H]IPP as substrate incubated for 10 mins prior to substrate addition measured after 8 mins by scintillation counting analysis	B	8.28	pIC50	5.2	nM	IC50	J Med Chem (2013) 56: 7939-7950 [PMID:23998921]
GtoPdb	-	-	8.41	pIC50	3.9	nM	IC50	Arch Biochem Biophys (2000) 373: 231-41 [PMID:10620343]
ChEMBL	Inhibition of human FPPS using pre-incubation of compound with enzyme	B	9.44	pIC50	0.36	nM	IC50	ACS Med Chem Lett (2015) 6: 349-354 [PMID:25815158]
Farnesyl pyrophosphate synthase in Leishmania donovani (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3693] [UniProtKB: Q0GKD7]
ChEMBL	Binding affinity towards Farnesyl diphosphate synthase from leishmania major	B	7.77	pKi	17	nM	Ki	J Med Chem (2005) 48: 2957-2963 [PMID:15828834]
ChEMBL	Inhibitory activity against Leishmania major Farnesyl diphosphate synthase	B	6.77	pIC50	170	nM	IC50	J Med Chem (2004) 47: 175-187 [PMID:14695831]
ChEMBL	Inhibitory activity against FPPS in Leishmania major	B	6.77	pIC50	170	nM	IC50	J Med Chem (2006) 49: 215-223 [PMID:16392806]
ChEMBL	Inhibitory activity against FPPS in Leishmania major	B	6.77	pIC50	169.82	nM	IC50	J Med Chem (2006) 49: 215-223 [PMID:16392806]
Farnesyl pyrophosphate synthase in Leishmania major (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2150832] [UniProtKB: Q4QBL1]
ChEMBL	Inhibition of recombinant Leishmania major FPPS expressed in Escherichia coli BL21(DE3) using GPP and [14C]IPP as substrate incubated for 15 mins by scintillation counting method	B	7.8	pKi	16	nM	Ki	Bioorg Med Chem Lett (2020) 30: 127577-127577 [PMID:32979487]
geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749]
ChEMBL	Inhibition of human recombinant N-terminal His6 tagged GGPPS expressed in Escherichia coli BL21 using FPP and [14C]IPP as substrate incubated for 10 mins prior to substrate addition by scintillation counting	B	4	pIC50	>100000	nM	IC50	J Med Chem (2012) 55: 3201-3215 [PMID:22390415]
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL	Antimalarial activity against Plasmodium berghei NK65 infected in human HepG2 cells after 48 hrs by RT-PCR	F	4.8	pIC50	16000	nM	IC50	Antimicrob Agents Chemother (2010) 54: 2987-2993 [PMID:20457823]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2mef assessed as suppression of parasitemia by microscopic analysis	F	5.85	pIC50	1400	nM	IC50	Antimicrob Agents Chemother (2010) 54: 2987-2993 [PMID:20457823]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as suppression of parasitemia by microscopic analysis	F	5.92	pIC50	1200	nM	IC50	Antimicrob Agents Chemother (2010) 54: 2987-2993 [PMID:20457823]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]