SQ-34919 [Ligand Id: 3101] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL286760 (SQ-34919) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase in Bovine (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095178] [UniProtKB: P29702, P49355] | ||||||||
| ChEMBL | Inhibition of Farnesyltransferase from bovine brain | B | 4.1 | pIC50 | 80000 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 1291-1296 |
| squalene synthase /Squalene synthetase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769] | ||||||||
| ChEMBL | Inhibition of squalene synthase from rat liver microsomes | B | 7.77 | pIC50 | 17 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 1291-1296 |
| GtoPdb | Inhibition rat liver microsomal squalene synthase | - | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (1995) 38: 2596-605 [PMID:7629799] |
| GtoPdb | Inhibitory activity against rat liver microsomal squalene synthase was determined using [3H]-FPP as radioligand | - | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (1996) 39: 657-60 [PMID:8576905] |
| ChEMBL | Inhibition rat liver microsomal squalene synthase | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (1995) 38: 2596-2605 [PMID:7629799] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
