compound 5d [PMID: 7966163] [Ligand Id: 3082] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL441322 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| squalene synthase /Squalene synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3338] [GtoPdb: 645] [UniProtKB: P37268] | ||||||||
| ChEMBL | compound required to inhibit 50% activity of yeast squalene synthase enzyme (YESS) | B | 9.19 | pIC50 | 0.64 | nM | IC50 | J Med Chem (1994) 37: 4031-4051 [PMID:7966163] |
| squalene synthase /Squalene synthetase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769] | ||||||||
| ChEMBL | Tested for inhibition against squalene synthase enzyme in rat liver | B | 10.4 | pIC50 | 0.04 | nM | IC50 | J Med Chem (1994) 37: 4031-4051 [PMID:7966163] |
| GtoPdb | Tested for inhibition against squalene synthase enzyme in rat liver | - | 10.4 | pIC50 | 0.04 | nM | IC50 | J Med Chem (1994) 37: 4031-51 [PMID:7966163] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
