ChEMBL ligand: CHEMBL997 (Acide ibandronique, Acido ibandronico, Bondenza, Bondronat, Boniva, Bonviva, Iasibon, Ibandronate, Ibandronic acid, Ibandronic Acid, Ibandronic acid accord, Ibandronic acid sandoz, Ibandronic acid teva, NSC-722623, Quodixor)
farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324] farnesyl diphosphate synthase in Rat [GtoPdb: 644] [UniProtKB: P05369] There should be some charts here, you may need to enable JavaScript!
geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
squalene synthase /Squalene synthetase in Rat [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324]
ChEMBL	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21	B	6.71	pKi	195	nM	Ki	J Med Chem (2008) 51: 2187-2195 [PMID:18327899]
GtoPdb	-	-	6.71	pKi	195	nM	Ki	J Med Chem (2008) 51: 2187-95 [PMID:18327899]
ChEMBL	Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligand	B	7.34	pKi	46	nM	Ki	J Med Chem (2003) 46: 5171-5183 [PMID:14613320]
ChEMBL	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins	B	8.44	pKi	3.6	nM	Ki	J Med Chem (2008) 51: 2187-2195 [PMID:18327899]
ChEMBL	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21	B	5.98	pIC50	1052	nM	IC50	J Med Chem (2008) 51: 2187-2195 [PMID:18327899]
ChEMBL	Inhibitory activity against farnesyl Pyrophosphate Synthase was determined	B	6.32	pIC50	480	nM	IC50	J Med Chem (2003) 46: 5171-5183 [PMID:14613320]
ChEMBL	Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME? (M)	B	6.32	pIC50	478.63	nM	IC50	J Med Chem (2003) 46: 5171-5183 [PMID:14613320]
ChEMBL	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins	B	7.6	pIC50	25.4	nM	IC50	J Med Chem (2008) 51: 2187-2195 [PMID:18327899]
ChEMBL	Inhibitory activity against the human recombinant FPPSase (Farnesyl diphosphate) enzyme	B	7.7	pIC50	20	nM	IC50	J Med Chem (2002) 45: 2185-2196 [PMID:12014956]
ChEMBL	Inhibition of human recombinant FPP synthase	B	7.7	pIC50	20	nM	IC50	J Med Chem (2021) 64: 9677-9710 [PMID:34236862]
farnesyl diphosphate synthase in Rat [GtoPdb: 644] [UniProtKB: P05369]
GtoPdb	in vitro using kidney cell lines	-	5.13	pIC50	7400	nM	-	Toxicol In Vitro (2008) 22: 899-909 [PMID:18325729]
geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749]
ChEMBL	Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase).	B	4.08	pIC50	83000	nM	IC50	J Med Chem (2002) 45: 2185-2196 [PMID:12014956]
ChEMBL	Inhibition of human recombinant geranylgeranyl diphosphate synthase	B	4.1	pIC50	79432.82	nM	IC50	J Med Chem (2008) 51: 5594-5607 [PMID:18800762]
ChEMBL	Inhibition of human recombinant geranylgeranyl diphosphate synthase	B	4.1	pIC50	79430	nM	IC50	J Med Chem (2008) 51: 5594-5607 [PMID:18800762]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Growth inhibition of Plasmodium falciparum	F	4.1	pIC50	79432.82	nM	IC50	J Med Chem (2008) 51: 7827-7833 [PMID:19053772]
ChEMBL	Growth inhibition of Plasmodium falciparum	F	4.13	pIC50	74000	nM	IC50	J Med Chem (2008) 51: 7827-7833 [PMID:19053772]
ChEMBL	Antimicrobial activity against Plasmodium falciparum	F	4.23	pIC50	59000	nM	IC50	Bioorg Med Chem (2010) 18: 2225-2231 [PMID:20185316]
squalene synthase /Squalene synthetase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769]
GtoPdb	Inhibition of squalene synthase in rat liver microsomes assessed as conversion of [1-3H]FPP to [3H]squalene level after 60 mins by liquid scintillation counting	-	6.19	pIC50	640	nM	IC50	Bioorg Med Chem (2010) 18: 2428-38 [PMID:20299227]
ChEMBL	Inhibition of squalene synthase in rat liver microsomes assessed as conversion of [1-3H]FPP to [3H]squalene level after 60 mins by liquid scintillation counting	B	6.19	pIC50	640	nM	IC50	Bioorg Med Chem (2010) 18: 2428-2438 [PMID:20299227]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]