geranylgeranyl diphosphate [Ligand Id: 3052] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1229266
  • mevalonate kinase in Human [GtoPdb: 640] [UniProtKB: Q03426]
Created with Highcharts 10.3.3ValuesChart context menumevalonate kinasepKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • geranylgeranyl diphosphate synthase in Human [GtoPdb: 643] [UniProtKB: O95749]
Created with Highcharts 10.3.3ValuesChart context menugeranylgeranyl diphosphate synthasepKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mevalonate kinase in Human [GtoPdb: 640] [UniProtKB: Q03426]
GtoPdb recombinant enzyme expressed in E coli cells. Spectrophotometric assay - 7.23 pKi 59 nM Ki J Lipid Res (1997) 38: 2216-23 [PMID:9392419]
geranylgeranyl diphosphate synthase in Human [GtoPdb: 643] [UniProtKB: O95749]
GtoPdb recombinant human protein expressed in E coli, in vitro assay - 4.6 pKi 25000 nM - J Biol Chem (2006) 281: 22004-12 [PMID:16698791]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]