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ChEMBL ligand: CHEMBL41342 (Geranyl Diphosphate) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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mevalonate kinase in Human [GtoPdb: 640] [UniProtKB: Q03426] | ||||||||
GtoPdb | recombinant enzyme expressed in E coli cells. Spectrophotometric assay | - | 6.94 | pKi | 116 | nM | Ki | J Lipid Res (1997) 38: 2216-23 [PMID:9392419] |
mevalonate kinase in Rat [GtoPdb: 640] [UniProtKB: P17256] | ||||||||
GtoPdb | in vitro assay, enzyme expressed in E coli, purified | - | 5.3 | pIC50 | 5000 | nM | IC50 | Org Lett (2006) 8: 1013-6 [PMID:16524256] |
diphosphomevalonate decarboxylase in Rat [GtoPdb: 642] [UniProtKB: Q62967] | ||||||||
GtoPdb | expression of rat enzyme in E coli, purification, in vitro spectrophotometric assay | - | 5.3 | pIC50 | 5000 | nM | IC50 |
Biochim Biophys Acta (2006) 1760: 1080-7 [PMID:16626865]; Org Lett (2006) 8: 1013-6 [PMID:16524256] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]