ChEMBL ligand: CHEMBL69330 (Farnesyl Diphosphate)
Farnesyltransferase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL2111393] [UniProtKB: P22007, P29703] There should be some charts here, you may need to enable JavaScript!
farnesyltransferase, CAAX box, subunit alpha/farnesyltransferase, CAAX box, subunit beta/Protein farnesyltransferase in Human [ChEMBL: CHEMBL2094108] [GtoPdb: 2825, 2826] [UniProtKB: P49354, P49356] There should be some charts here, you may need to enable JavaScript!
squalene synthase /Squalene synthetase in Rat [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769] There should be some charts here, you may need to enable JavaScript!
mevalonate kinase in Human [GtoPdb: 640] [UniProtKB: Q03426] mevalonate kinase in Rat [GtoPdb: 640] [UniProtKB: P17256] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Farnesyltransferase in Saccharomyces cerevisiae S288c (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111393] [UniProtKB: P22007, P29703]
ChEMBL	Inhibition of yeast Farnesyl transferase	B	7.12	pKd	75	nM	Kd	Bioorg Med Chem Lett (1997) 7: 2125-2130
farnesyltransferase, CAAX box, subunit alpha/farnesyltransferase, CAAX box, subunit beta/Protein farnesyltransferase in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094108] [GtoPdb: 2825, 2826] [UniProtKB: P49354, P49356]
ChEMBL	Binding affinity to FTase (unknown origin)	B	8.7	pKd	2	nM	Kd	Medchemcomm (2013) 4: 476-492 [PMID:25530833]
squalene synthase /Squalene synthetase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769]
ChEMBL	Inhibitory activity against microsomal Squalene synthase	B	5.59	pKi	2600	nM	Ki	J Med Chem (1991) 34: 1912-1914 [PMID:2061928]
mevalonate kinase in Human [GtoPdb: 640] [UniProtKB: Q03426]
GtoPdb	recombinant enzyme expressed in E coli cells. Spectrophotometric assay	-	7	pKi	101	nM	Ki	J Lipid Res (1997) 38: 2216-23 [PMID:9392419]
GtoPdb	recombinant wild type enzyme expressed in E coli, in vitro spectrophotometric assay	-	7.47	pKi	34	nM	Ki	Biochemistry (2008) 47: 3715-24 [PMID:18302342]
mevalonate kinase in Rat [GtoPdb: 640] [UniProtKB: P17256]
GtoPdb	in vitro, spectrophotometric assay	-	5.6	pKi	2500	nM	Ki	J Biol Chem (1990) 265: 2391-8 [PMID:2153681]
GtoPdb	spectrophotometric in vitro assay	-	6.46	pKi	348	nM	Ki	J Bacteriol (2004) 186: 61-7 [PMID:14679225]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]