isopentenyl diphosphate [Ligand Id: 3048] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL356362 (Isopentenylpyrophosphate, Isopentenyl Pyrophosphate) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| butyrophilin subfamily 3 member A1/Butyrophilin subfamily 3 member A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105758] [GtoPdb: 2948] [UniProtKB: O00481] | ||||||||
| ChEMBL | Activation of BTN3A1 in human PBMC-derived Vgamma9/Vdelta2 T cells assessed as induction of IL2-stimulated IFNgamma production measured after 48 hrs by ELISA | B | 4.15 | pEC50 | 71000 | nM | EC50 | J Med Chem (2019) 62: 6814-6823 [PMID:31268699] |
| ChEMBL | Activation of BTN3A1 in human PBMC-derived Vgamma9/Vdelta2 T cells assessed as induction of IL2-stimulated cell proliferation by measuring increase in CD3+ cells preincubated for 3 days followed by 11 days incubation post compound washout and subsequent IL2 stimulation for every 3 days measured after 14 days by flow cytometry | B | 4.44 | pEC50 | 36000 | nM | EC50 | J Med Chem (2019) 62: 6814-6823 [PMID:31268699] |
| ChEMBL | Binding affinity to BTN3A1 in human PBMC-derived Vgamma9/Vdelta2 T cells | B | 6 | pEC50 | 1000 | nM | EC50 | J Med Chem (2020) 63: 11258-11270 [PMID:32930595] |
| TRPA1 in Mouse [GtoPdb: 485] [UniProtKB: Q8BLA8] | ||||||||
| GtoPdb | Calcium imaging | - | 5.1 | pIC50 | - | - | - | Br J Pharmacol (2010) 161: 707-20 [PMID:20880407] |
| TRPV3 in Human [GtoPdb: 509] [UniProtKB: Q8NET8] | ||||||||
| GtoPdb | Calcium imaging | - | 6.62 | pIC50 | 239 | nM | IC50 | Pain (2011) 152: 1156-64 [PMID:21353389] |
| mevalonate kinase in Human [GtoPdb: 640] [UniProtKB: Q03426] | ||||||||
| GtoPdb | recombinant enzyme expressed in E coli cells. Spectrophotometric assay | - | 4.8 | pKi | 16000 | nM | Ki | J Lipid Res (1997) 38: 2216-23 [PMID:9392419] |
| farnesyl diphosphate synthase in Human [GtoPdb: 644] [UniProtKB: P14324] | ||||||||
| GtoPdb | value not verified | - | 6.15 | pKi | 700 | nM | - | Meth Enzymol (1985) 110: 155-67 [PMID:4021811] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
