ChEMBL ligand: CHEMBL54440 (Mevastatin, NSC-759322)
hydroxymethylglutaryl-CoA reductase/HMG-CoA reductase in Human [ChEMBL: CHEMBL402] [GtoPdb: 639] [UniProtKB: P04035] hydroxymethylglutaryl-CoA reductase/HMG-CoA reductase in Rat [ChEMBL: CHEMBL3247] [GtoPdb: 639] [UniProtKB: P51639] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
hydroxymethylglutaryl-CoA reductase/HMG-CoA reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL402] [GtoPdb: 639] [UniProtKB: P04035]
ChEMBL	DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA)	B	6.92	pIC50	119	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	The compound was tested in vitro for inhibitory activity against HMG-CoA reductase	B	7.55	pIC50	28.4	nM	IC50	J Med Chem (1992) 35: 3813-3821 [PMID:1433193]
ChEMBL	Inhibitory concentration against 3-hydroxy-3-methylglutaryl-CoA reductase	B	7.64	pIC50	23	nM	IC50	Bioorg Med Chem Lett (2005) 15: 1027-1032 [PMID:15686906]
ChEMBL	Inhibition of HMG-CoA Reductase (unknown origin)	B	7.64	pIC50	23	nM	IC50	J Med Chem (2019) 62: 10005-10025 [PMID:31188592]
GtoPdb	-	-	7.64	pIC50	23	nM	IC50	Bioorg Med Chem Lett (2005) 15: 1027-32 [PMID:15686906]
hydroxymethylglutaryl-CoA reductase/HMG-CoA reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3247] [GtoPdb: 639] [UniProtKB: P51639]
GtoPdb	-	-	8.85	pKi	1.4	nM	Ki	J Med Chem (1987) 30: 1858-73 [PMID:3656359]
ChEMBL	Binding affinity against HMG-CoA reductase in rat liver microsomes	B	8.85	pKi	1.4	nM	Ki	J Med Chem (1987) 30: 1858-1873 [PMID:3656359]
GtoPdb	in vitro inhibition of HMG-CoA reductase	-	9	pKi	1	nM	Ki	J Med Chem (1985) 28: 401-5 [PMID:3981532]
ChEMBL	Binding affinity was determined against purified rat liver HMG-coA reductase enzyme	B	9	pKi	~1	nM	Ki	J Med Chem (1985) 28: 401-405 [PMID:3981532]
ChEMBL	Tested in vitro for the HMG-CoA reductase inhibitory activity in a microsomal preparation	B	5.94	pIC50	1150	nM	IC50	Bioorg Med Chem Lett (1997) 7: 549-554
GtoPdb	in vitro inhibition of HMG-CoA reductase	-	5.94	pIC50	1150	nM	IC50	Bioorg Med Chem Lett (1997) 7: 549-554
GtoPdb	in vitro inhibition of HMG-CoA reductase	-	6	pIC50	1000	nM	IC50	J Med Chem (1985) 28: 597-601 [PMID:3989819]
GtoPdb	-	-	6	pIC50	1000	nM	IC50	J Med Chem (1985) 28: 597-601 [PMID:3989819]
ChEMBL	Inhibition of HMG-CoA reductase from rat liver	B	6	pIC50	1000	nM	IC50	J Med Chem (1985) 28: 597-601 [PMID:3989819]
GtoPdb	in vitro inhibition of HMG-CoA reductase	-	7	pIC50	110	nM	IC50	Bioorg Med Chem Lett (1997) 7: 549-554
ChEMBL	Inhibition of rat HMG-CoA reductase using 0.37 MBq DL-[3-14C]HMG-CoA	B	7.4	pIC50	40	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4228-4231 [PMID:19502059]
GtoPdb	in vitro inhibition of HMG-CoA reductase	-	7.4	pIC50	40	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4228-31 [PMID:19502059]
GtoPdb	in vitro inhibition of HMG-CoA reductase	-	7.52	pIC50	30	nM	IC50	J Med Chem (1991) 34: 357-66 [PMID:1992137]
ChEMBL	Inhibition of HMG-CoA reductase activity in partially purified rat liver	B	7.52	pIC50	30	nM	IC50	J Med Chem (1991) 34: 357-366 [PMID:1992137]
ChEMBL	Ability to inhibit HMG-CoA reductase (HMGR) by cholesterol synthesis inhibition screen (CSI) in rats	B	7.59	pIC50	26	nM	IC50	J Med Chem (1990) 33: 21-31 [PMID:2296019]
ChEMBL	Ability to inhibit HMG-CoA reductase (HMGR) by cholesterol synthesis inhibition screen (CSI) in rats	B	7.6	pIC50	25.12	nM	IC50	J Med Chem (1990) 33: 21-31 [PMID:2296019]
ChEMBL	Ability to inhibit HMG-CoA reductase (HMGR) by CoA reductase inhibition screen (COR) in rats	B	7.6	pIC50	25.12	nM	IC50	J Med Chem (1990) 33: 21-31 [PMID:2296019]
GtoPdb	in vitro inhibition of HMG-CoA reductase	-	7.6	pIC50	25	nM	IC50	J Med Chem (1991) 34: 367-73 [PMID:1992138]
ChEMBL	Compound was evaluated for the inhibition of HMG-CoA reductase (COR) in rats.	B	7.6	pIC50	25	nM	IC50	J Med Chem (1991) 34: 367-373 [PMID:1992138]
ChEMBL	Ability to inhibit HMG-CoA reductase (HMGR) by CoA reductase inhibition screen (COR) in rats	B	7.6	pIC50	25	nM	IC50	J Med Chem (1990) 33: 21-31 [PMID:2296019]
ChEMBL	Inhibition of HMG-CoA reductase in rat liver microsomes	B	7.89	pIC50	13	nM	IC50	J Med Chem (1987) 30: 1858-1873 [PMID:3656359]
GtoPdb	in vitro inhibition of HMG-CoA reductase	-	8	pIC50	10	nM	IC50	J Med Chem (1985) 28: 347-58 [PMID:3973903]
ChEMBL	In vitro inhibitory activity against HMG CoA reductase	B	8	pIC50	10	nM	IC50	J Med Chem (1985) 28: 347-358 [PMID:3973903]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]