ChEMBL ligand: CHEMBL54440 (Mevastatin, Mevastatina, Mevastatine, NSC-759322)
hydroxymethylglutaryl-CoA reductase/HMG-CoA reductase in Human [ChEMBL: CHEMBL402] [GtoPdb: 639] [UniProtKB: P04035] hydroxymethylglutaryl-CoA reductase/HMG-CoA reductase in Rat [ChEMBL: CHEMBL3247] [GtoPdb: 639] [UniProtKB: P51639] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
hydroxymethylglutaryl-CoA reductase/HMG-CoA reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL402] [GtoPdb: 639] [UniProtKB: P04035]
ChEMBL	DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA)	B	6.92	pIC50	119	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	The compound was tested in vitro for inhibitory activity against HMG-CoA reductase	B	7.55	pIC50	28.4	nM	IC50	J Med Chem (1992) 35: 3813-3821 [PMID:1433193]
ChEMBL	Inhibitory concentration against 3-hydroxy-3-methylglutaryl-CoA reductase	B	7.64	pIC50	23	nM	IC50	Bioorg Med Chem Lett (2005) 15: 1027-1032 [PMID:15686906]
ChEMBL	Inhibition of HMG-CoA Reductase (unknown origin)	B	7.64	pIC50	23	nM	IC50	J Med Chem (2019) 62: 10005-10025 [PMID:31188592]
GtoPdb	-	-	7.64	pIC50	23	nM	IC50	Bioorg Med Chem Lett (2005) 15: 1027-32 [PMID:15686906]
hydroxymethylglutaryl-CoA reductase/HMG-CoA reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3247] [GtoPdb: 639] [UniProtKB: P51639]
GtoPdb	-	-	8.85	pKi	1.4	nM	Ki	J Med Chem (1987) 30: 1858-73 [PMID:3656359]
ChEMBL	Binding affinity against HMG-CoA reductase in rat liver microsomes	B	8.85	pKi	1.4	nM	Ki	J Med Chem (1987) 30: 1858-1873 [PMID:3656359]
GtoPdb	in vitro inhibition of HMG-CoA reductase	-	9	pKi	1	nM	Ki	J Med Chem (1985) 28: 401-5 [PMID:3981532]
ChEMBL	Binding affinity was determined against purified rat liver HMG-coA reductase enzyme	B	9	pKi	~1	nM	Ki	J Med Chem (1985) 28: 401-405 [PMID:3981532]
ChEMBL	Tested in vitro for the HMG-CoA reductase inhibitory activity in a microsomal preparation	B	5.94	pIC50	1150	nM	IC50	Bioorg Med Chem Lett (1997) 7: 549-554
GtoPdb	in vitro inhibition of HMG-CoA reductase	-	5.94	pIC50	1150	nM	IC50	Bioorg Med Chem Lett (1997) 7: 549-554
GtoPdb	in vitro inhibition of HMG-CoA reductase	-	6	pIC50	1000	nM	IC50	J Med Chem (1985) 28: 597-601 [PMID:3989819]
GtoPdb	-	-	6	pIC50	1000	nM	IC50	J Med Chem (1985) 28: 597-601 [PMID:3989819]
ChEMBL	Inhibition of HMG-CoA reductase from rat liver	B	6	pIC50	1000	nM	IC50	J Med Chem (1985) 28: 597-601 [PMID:3989819]
GtoPdb	in vitro inhibition of HMG-CoA reductase	-	7	pIC50	110	nM	IC50	Bioorg Med Chem Lett (1997) 7: 549-554
ChEMBL	Inhibition of rat HMG-CoA reductase using 0.37 MBq DL-[3-14C]HMG-CoA	B	7.4	pIC50	40	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4228-4231 [PMID:19502059]
GtoPdb	in vitro inhibition of HMG-CoA reductase	-	7.4	pIC50	40	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4228-31 [PMID:19502059]
GtoPdb	in vitro inhibition of HMG-CoA reductase	-	7.52	pIC50	30	nM	IC50	J Med Chem (1991) 34: 357-66 [PMID:1992137]
ChEMBL	Inhibition of HMG-CoA reductase activity in partially purified rat liver	B	7.52	pIC50	30	nM	IC50	J Med Chem (1991) 34: 357-366 [PMID:1992137]
ChEMBL	Ability to inhibit HMG-CoA reductase (HMGR) by cholesterol synthesis inhibition screen (CSI) in rats	B	7.59	pIC50	26	nM	IC50	J Med Chem (1990) 33: 21-31 [PMID:2296019]
ChEMBL	Ability to inhibit HMG-CoA reductase (HMGR) by cholesterol synthesis inhibition screen (CSI) in rats	B	7.6	pIC50	25.12	nM	IC50	J Med Chem (1990) 33: 21-31 [PMID:2296019]
ChEMBL	Ability to inhibit HMG-CoA reductase (HMGR) by CoA reductase inhibition screen (COR) in rats	B	7.6	pIC50	25.12	nM	IC50	J Med Chem (1990) 33: 21-31 [PMID:2296019]
GtoPdb	in vitro inhibition of HMG-CoA reductase	-	7.6	pIC50	25	nM	IC50	J Med Chem (1991) 34: 367-73 [PMID:1992138]
ChEMBL	Compound was evaluated for the inhibition of HMG-CoA reductase (COR) in rats.	B	7.6	pIC50	25	nM	IC50	J Med Chem (1991) 34: 367-373 [PMID:1992138]
ChEMBL	Ability to inhibit HMG-CoA reductase (HMGR) by CoA reductase inhibition screen (COR) in rats	B	7.6	pIC50	25	nM	IC50	J Med Chem (1990) 33: 21-31 [PMID:2296019]
ChEMBL	Inhibition of HMG-CoA reductase in rat liver microsomes	B	7.89	pIC50	13	nM	IC50	J Med Chem (1987) 30: 1858-1873 [PMID:3656359]
GtoPdb	in vitro inhibition of HMG-CoA reductase	-	8	pIC50	10	nM	IC50	J Med Chem (1985) 28: 347-58 [PMID:3973903]
ChEMBL	In vitro inhibitory activity against HMG CoA reductase	B	8	pIC50	10	nM	IC50	J Med Chem (1985) 28: 347-358 [PMID:3973903]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]