methylfurmethide [Ligand Id: 300] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL92387 (5-Methylfurmethide)
  • M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
  • M1 receptor/Muscarinic acetylcholine receptor M1 in Rat [ChEMBL: CHEMBL276] [GtoPdb: 13] [UniProtKB: P08482]
  • 0
1 CHEMBL92387_lig_chart_1 Muscarinic acetylcholine receptor M1 HumanRat
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  • M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
  • 5.46
2 CHEMBL92387_lig_chart_2 Muscarinic acetylcholine receptor M2 Human
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  • M3 receptor/Muscarinic acetylcholine receptor M3 in Human [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
  • 4.9
3 CHEMBL92387_lig_chart_3 Muscarinic acetylcholine receptor M3 Human
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  • M4 receptor/Muscarinic acetylcholine receptor M4 in Human [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173]
  • 4.95
4 CHEMBL92387_lig_chart_4 Muscarinic acetylcholine receptor M4 Human
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  • M5 receptor/Muscarinic acetylcholine receptor M5 in Human [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912]
  • This target only has 1 pki data point
  • 5.16
5 CHEMBL92387_lig_chart_5 Muscarinic acetylcholine receptor M5 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
GtoPdb - - 4.6 pKi - - - Mol Pharmacol (1997) 52: 172-9 [PMID:9224827]
ChEMBL Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO cells by liquid scintillation counter B 5.1 pKi 7943.28 nM Ki J. Med. Chem. (2008) 51: 3905-3912 [PMID:18543900]
M1 receptor/Muscarinic acetylcholine receptor M1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL276] [GtoPdb: 13] [UniProtKB: P08482]
ChEMBL Ability to displace [3H]pirenzepine (pir) from muscarinic acetylcholine receptor M1 in rat cortical tissue. B 5.85 pIC50 1410 nM IC50 J. Med. Chem. (1992) 35: 15-27 [PMID:1732522]
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
GtoPdb - - 4.9 pKi - - - Mol Pharmacol (1997) 52: 172-9 [PMID:9224827]
ChEMBL Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter B 6.02 pKi 954.99 nM Ki J. Med. Chem. (2008) 51: 3905-3912 [PMID:18543900]
M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
GtoPdb - - 4.6 pKi - - - Mol Pharmacol (1997) 52: 172-9 [PMID:9224827]
ChEMBL Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO cells by liquid scintillation counter B 5.21 pKi 6165.95 nM Ki J. Med. Chem. (2008) 51: 3905-3912 [PMID:18543900]
M4 receptor/Muscarinic acetylcholine receptor M4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173]
GtoPdb - - 4.7 pKi - - - Mol Pharmacol (1997) 52: 172-9 [PMID:9224827]
ChEMBL Displacement of [3H]NMS from human muscarinic M4 receptor expressed in CHO cells by liquid scintillation counter B 5.2 pKi 6309.57 nM Ki J. Med. Chem. (2008) 51: 3905-3912 [PMID:18543900]
M5 receptor/Muscarinic acetylcholine receptor M5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912]
ChEMBL Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells by liquid scintillation counter B 5.16 pKi 6918.31 nM Ki J. Med. Chem. (2008) 51: 3905-3912 [PMID:18543900]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]