methylfurmethide [Ligand Id: 300] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL92387 (5-Methylfurmethide) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229] | ||||||||
| GtoPdb | - | - | 4.6 | pKi | - | - | - | Mol Pharmacol (1997) 52: 172-9 [PMID:9224827] |
| ChEMBL | Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO cells by liquid scintillation counter | B | 5.1 | pKi | 7943.28 | nM | Ki | J Med Chem (2008) 51: 3905-3912 [PMID:18543900] |
| M1 receptor/Muscarinic acetylcholine receptor M1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL276] [GtoPdb: 13] [UniProtKB: P08482] | ||||||||
| ChEMBL | Ability to displace [3H]pirenzepine (pir) from muscarinic acetylcholine receptor M1 in rat cortical tissue. | B | 5.85 | pIC50 | 1410 | nM | IC50 | J Med Chem (1992) 35: 15-27 [PMID:1732522] |
| M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172] | ||||||||
| GtoPdb | - | - | 4.9 | pKi | - | - | - | Mol Pharmacol (1997) 52: 172-9 [PMID:9224827] |
| ChEMBL | Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter | B | 6.02 | pKi | 954.99 | nM | Ki | J Med Chem (2008) 51: 3905-3912 [PMID:18543900] |
| M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309] | ||||||||
| GtoPdb | - | - | 4.6 | pKi | - | - | - | Mol Pharmacol (1997) 52: 172-9 [PMID:9224827] |
| ChEMBL | Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO cells by liquid scintillation counter | B | 5.21 | pKi | 6165.95 | nM | Ki | J Med Chem (2008) 51: 3905-3912 [PMID:18543900] |
| M4 receptor/Muscarinic acetylcholine receptor M4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173] | ||||||||
| GtoPdb | - | - | 4.7 | pKi | - | - | - | Mol Pharmacol (1997) 52: 172-9 [PMID:9224827] |
| ChEMBL | Displacement of [3H]NMS from human muscarinic M4 receptor expressed in CHO cells by liquid scintillation counter | B | 5.2 | pKi | 6309.57 | nM | Ki | J Med Chem (2008) 51: 3905-3912 [PMID:18543900] |
| M5 receptor/Muscarinic acetylcholine receptor M5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912] | ||||||||
| ChEMBL | Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells by liquid scintillation counter | B | 5.16 | pKi | 6918.31 | nM | Ki | J Med Chem (2008) 51: 3905-3912 [PMID:18543900] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
