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ChEMBL ligand: CHEMBL1482 (Bethanechol) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Muscarinic acetylcholine receptor M3 in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5498] [UniProtKB: Q8VH26] | ||||||||
ChEMBL | Binding affinity to muscarinic M3 receptor in guinea-pig ileum | B | 4.9 | pKd | 12589.25 | nM | Kd | Bioorg Med Chem (2007) 15: 7626-7637 [PMID:17889543] |
ChEMBL | Agonist activity at muscarinic M3 receptor in guinea-pig ileum | F | 6.37 | pEC50 | 426.58 | nM | EC50 | Bioorg Med Chem (2007) 15: 7626-7637 [PMID:17889543] |
Muscarinic receptor 2 in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075061] [UniProtKB: Q8VH27] | ||||||||
ChEMBL | Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response | B | 5.85 | pEC50 | 1412.54 | nM | EC50 | Eur J Med Chem (2014) 75: 222-232 [PMID:24534538] |
ChEMBL | Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response | B | 6 | pEC50 | 1000 | nM | EC50 | Eur J Med Chem (2014) 75: 222-232 [PMID:24534538] |
M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229] | ||||||||
GtoPdb | - | - | 4 | pKi | - | - | - |
Br J Pharmacol (1995) 114: 1241-9 [PMID:7620715]; Mol Pharmacol (1997) 52: 172-9 [PMID:9224827] |
M1 receptor in Rat [GtoPdb: 13] [UniProtKB: P08482] | ||||||||
GtoPdb | - | - | 3.7 | pKi | - | - | - | J Pharmacol Exp Ther (1989) 248: 661-70 [PMID:2537406] |
M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172] | ||||||||
GtoPdb | - | - | 4 | pKi | - | - | - |
Br J Pharmacol (1995) 114: 1241-9 [PMID:7620715]; Mol Pharmacol (1997) 52: 172-9 [PMID:9224827] |
M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309] | ||||||||
GtoPdb | - | - | 4.2 | pKi | - | - | - |
Br J Pharmacol (1995) 114: 1241-9 [PMID:7620715]; Mol Pharmacol (1997) 52: 172-9 [PMID:9224827] |
M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173] | ||||||||
GtoPdb | - | - | 4 | pKi | - | - | - |
Br J Pharmacol (1995) 114: 1241-9 [PMID:7620715]; Mol Pharmacol (1997) 52: 172-9 [PMID:9224827] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]