fluvastatin [Ligand Id: 2951] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1078 (Fluvastatin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| hydroxymethylglutaryl-CoA reductase in Human [GtoPdb: 639] [UniProtKB: P04035] | ||||||||
| GtoPdb | In vitro inhibition of HMG-CoA reductase | - | 6.56 | pKi | 256 | nM | Ki | Biochemistry (2005) 44: 11741-8 [PMID:16128575] |
| GtoPdb | - | - | 7.55 | pKi | 28 | nM | Ki | Biochem Soc Trans (2003) 31: 528-31 [PMID:12773150] |
| GtoPdb | Inhibition of HMG-CoA reductase | - | 7.55 | pIC50 | 28 | nM | IC50 | Science (2001) 292: 1160-4 [PMID:11349148] |
| hydroxymethylglutaryl-CoA reductase in Rat [GtoPdb: 639] [UniProtKB: P51639] | ||||||||
| GtoPdb | in vitro inhibition of cholesterol synthesis | - | 8.42 | pIC50 | 3.78 | nM | IC50 | Am J Cardiol (2001) 87: 28B-32B [PMID:11256847] |
| GtoPdb | in vitro inhibition of HMG-CoA reductase | - | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 4228-31 [PMID:19502059] |
| GtoPdb | In vitro inhibition of HMG-CoA reductase | - | 8.6 | pIC50 | 2.5 | nM | IC50 | J Med Chem (1993) 36: 3674-85 [PMID:8246237] |
| GtoPdb | In vitro inhibition of HMG-CoA reductase | - | 8.6 | pIC50 | 2.5 | nM | IC50 | J Med Chem (1991) 34: 2962-83 [PMID:1656041] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
