NS11757 [Ligand Id: 2944] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL511710 (NS-11757) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| KCa2.1/Small conductance calcium-activated potassium channel protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2369] [GtoPdb: 381] [UniProtKB: Q92952] | ||||||||
| ChEMBL | Inhibition of human SK1 channel by inside-out patch clamp technique | B | 7.27 | pKd | 54 | nM | Kd | J Med Chem (2008) 51: 7625-7634 [PMID:18998663] |
| KCa2.2/Small conductance calcium-activated potassium channel protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4469] [GtoPdb: 382] [UniProtKB: Q9H2S1] | ||||||||
| ChEMBL | Inhibition of human SK2 channel by inside-out patch clamp technique | B | 7.33 | pKd | 47 | nM | Kd | J Med Chem (2008) 51: 7625-7634 [PMID:18998663] |
| KCa2.3/Small conductance calcium-activated potassium channel protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3381] [GtoPdb: 383] [UniProtKB: Q9UGI6] | ||||||||
| ChEMBL | Inhibition of human SK3 channel by inside-out patch clamp technique | B | 7.22 | pKd | 60 | nM | Kd | J Med Chem (2008) 51: 7625-7634 [PMID:18998663] |
| ChEMBL | Inhibition of human SK3 channel expressed in HEK293 cells assessed as Ca2+ induced current after drug wash out by whole cell patch clamp technique in presence of bicuculline methobromide | B | 8.11 | pKd | 7.8 | nM | Kd | J Med Chem (2008) 51: 7625-7634 [PMID:18998663] |
| ChEMBL | Inhibition of wild type human SK3 channel expressed in HEK293 cells assessed as Ca2+ sensitivity by inside-out patch clamp technique | B | 5.74 | pEC50 | 1810 | nM | EC50 | J Med Chem (2008) 51: 7625-7634 [PMID:18998663] |
| KCa2.3/Small conductance calcium-activated potassium channel protein 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3780] [GtoPdb: 383] [UniProtKB: P70605] | ||||||||
| ChEMBL | Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique | B | 8.04 | pKd | 9.1 | nM | Kd | J Med Chem (2008) 51: 7625-7634 [PMID:18998663] |
| GtoPdb | - | - | 8.1 | pKd | - | - | - | J Med Chem (2008) 51: 7625-34 [PMID:18998663] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
