dioctanoylglycerol pyrophosphate [Ligand Id: 2916] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL191055 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| LPA1 receptor/Lysophosphatidic acid receptor Edg-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3819] [GtoPdb: 272] [UniProtKB: Q92633] | ||||||||
| GtoPdb | - | - | 5.18 | pKi | 6600 | nM | Ki |
Curr Med Chem (2008) 15: 2122-31 [PMID:18781939]; Mol Pharmacol (2001) 60: 776-84 [PMID:11562440] |
| ChEMBL | Binding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cells | B | 5.37 | pKi | 4300 | nM | Ki | J Med Chem (2005) 48: 4919-4930 [PMID:16033271] |
| ChEMBL | Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptor | F | 5.26 | pIC50 | 5500 | nM | IC50 | J Med Chem (2005) 48: 4919-4930 [PMID:16033271] |
| LPA3 receptor/Lysophosphatidic acid receptor Edg-7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3250] [GtoPdb: 274] [UniProtKB: Q9UBY5] | ||||||||
| ChEMBL | Binding affinity for Lysophosphatidic acid receptor 3 expressed in RH7777 rat hepatoma cells | B | 6.69 | pKi | 202 | nM | Ki | J Med Chem (2005) 48: 4919-4930 [PMID:16033271] |
| GtoPdb | - | - | 7 | pKi | 3330 | nM | Ki |
Mol Pharmacol (2003) 64: 994-1005 [PMID:14500756]; Mol Pharmacol (2001) 60: 776-84 [PMID:11562440] |
| ChEMBL | Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA3 receptor | F | 6.34 | pIC50 | 454 | nM | IC50 | J Med Chem (2005) 48: 4919-4930 [PMID:16033271] |
| GtoPdb | - | - | 6.97 | pIC50 | 106 | nM | IC50 | Mol Pharmacol (2001) 60: 776-84 [PMID:11562440] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
