eplerenone [Ligand Id: 2876] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1095097 (Eplerenona, Eplerenone, Inspra, SC-66110, SC-6611O) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Androgen receptor/Androgen Receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275] | ||||||||
| ChEMBL | Antagonist activity at androgen receptor (unknown origin) by NH Pro assay | B | 4.7 | pIC50 | >20000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4388-4392 [PMID:23777778] |
| ChEMBL | Displacement of [3H]-methyltrienolene from human androgen receptor incubated overnight by liquid scintillation counting analysis | B | 4.77 | pIC50 | 17000 | nM | IC50 | J Med Chem (2022) 65: 8127-8143 [PMID:35652647] |
| ChEMBL | Antagonist activity at androgen receptor | F | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 5979-6002 [PMID:20672822] |
| ChEMBL | Displacement of [3H]testosterone from AR | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2011) 54: 8616-8631 [PMID:22074142] |
| ChEMBL | Displacement of [3H]testosterone from androgen receptor (unknown origin) expressed in 293 cells after 16 hrs by scintillation counting | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem (2014) 22: 5428-5445 [PMID:25187277] |
| ChEMBL | Agonist activity at androgen receptor (unknown origin) by NH Pro assay | B | 4.7 | pEC50 | >20000 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 4388-4392 [PMID:23777778] |
| Estrogen receptor-α/Estrogen receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372] | ||||||||
| ChEMBL | Antagonist activity at estrogen receptor alpha (unknown origin) by NH Pro assay | B | 4.7 | pIC50 | >20000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4388-4392 [PMID:23777778] |
| ChEMBL | Antagonist activity at estrogen receptor | F | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 5979-6002 [PMID:20672822] |
| ChEMBL | Agonist activity at estrogen receptor alpha (unknown origin) by NH Pro assay | B | 4.7 | pEC50 | >20000 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 4388-4392 [PMID:23777778] |
| Estrogen receptor-β/Estrogen receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL242] [GtoPdb: 621] [UniProtKB: Q92731] | ||||||||
| ChEMBL | Displacement of [3H]-estradiol from recombinant full-length human estrogen beta receptor expressed in baculovirus infected insect cells incubated overnight by liquid scintillation counting analysis | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2022) 65: 8127-8143 [PMID:35652647] |
| ChEMBL | Antagonist activity at estrogen receptor beta (unknown origin) by NH Pro assay | B | 4.7 | pIC50 | >20000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4388-4392 [PMID:23777778] |
| ChEMBL | Agonist activity at estrogen receptor beta (unknown origin) by NH Pro assay | B | 4.7 | pEC50 | >20000 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 4388-4392 [PMID:23777778] |
| Glucocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150] | ||||||||
| ChEMBL | Binding affinity to recombinant human GR LBD by fluormone GS red-fluorescence polarization assay | B | 5.5 | pKi | 3162.28 | nM | Ki | J Med Chem (2019) 62: 1385-1406 [PMID:30596500] |
| ChEMBL | Displacement of [3H]-dexamethasone from recombinant full length human glucocorticoid receptor expressed in baculovirus infected insect cells incubated overnight by liquid scintillation counting analysis | B | 4.27 | pIC50 | 53800 | nM | IC50 | J Med Chem (2022) 65: 8127-8143 [PMID:35652647] |
| ChEMBL | Antagonist activity at glucocorticoid receptor (unknown origin) by NH Pro assay | B | 4.74 | pIC50 | 18000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4388-4392 [PMID:23777778] |
| ChEMBL | Displacement of [3H]dexomethasone from GR | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2011) 54: 8616-8631 [PMID:22074142] |
| ChEMBL | Antagonist activity at glucocorticoid receptor | F | 5.05 | pIC50 | >8940 | nM | IC50 | J Med Chem (2010) 53: 5979-6002 [PMID:20672822] |
| ChEMBL | Agonist activity at glucocorticoid receptor (unknown origin) by NH Pro assay | B | 4.7 | pEC50 | >20000 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 4388-4392 [PMID:23777778] |
| Mineralocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1994] [GtoPdb: 626] [UniProtKB: P08235] | ||||||||
| ChEMBL | Displacement of [3H]-aldosterone to human mineralocorticoid receptor LBD by radiometric binding assay | B | 6.9 | pKi | 125.89 | nM | Ki | J Med Chem (2019) 62: 1385-1406 [PMID:30596500] |
| GtoPdb | - | - | 6.91 | pKi | 124 | nM | Ki | J Med Chem (2007) 50: 6443-5 [PMID:18038968] |
| ChEMBL | Displacement of [3H]aldosterone from human mineralocorticoid receptor expressed in 293 cells after 16 hrs by scintillation counting | B | 5.59 | pIC50 | 2600 | nM | IC50 | Bioorg Med Chem (2014) 22: 5428-5445 [PMID:25187277] |
| ChEMBL | Displacement of [3H]aldosterone from cytosolic human MR expressed in HEK293 cells after 16 hrs by scintillation counting | B | 5.59 | pIC50 | 2600 | nM | IC50 | J Med Chem (2011) 54: 8616-8631 [PMID:22074142] |
| ChEMBL | Antagonist activity at human MR transfected in human COS1 cells after 1 day by luciferase reporter gene assay | F | 5.89 | pIC50 | 1300 | nM | IC50 | J Med Chem (2011) 54: 8616-8631 [PMID:22074142] |
| ChEMBL | Antagonist activity at human mineralocorticoid receptor expressed in COS1 cells after 1 day by luciferase reporter gene assay | B | 5.89 | pIC50 | 1300 | nM | IC50 | Bioorg Med Chem (2014) 22: 5428-5445 [PMID:25187277] |
| ChEMBL | Antagonist activity at gal4-fused human mineralocorticoid receptor LBD expressed in UAS-MR-bla HEK293 cells by luciferase reporter gene assay | B | 6.1 | pIC50 | 794.33 | nM | IC50 | J Med Chem (2019) 62: 1385-1406 [PMID:30596500] |
| ChEMBL | Antagonist activity at full length human mineralocorticoid receptor expressed in human U2OS cells by luciferase reporter gene assay | B | 6.4 | pIC50 | 398.11 | nM | IC50 | J Med Chem (2019) 62: 1385-1406 [PMID:30596500] |
| ChEMBL | Antagonist activity at mineralocorticoid receptor (unknown origin) by PathHunter assay | B | 6.61 | pIC50 | 244 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 1681-1684 [PMID:24630411] |
| ChEMBL | Antagonist activity at human full-length MCR assessed as inhibition of receptor binding to co-activator peptide by PathHunter assay | B | 6.61 | pIC50 | 244 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 2866-2869 [PMID:27161805] |
| ChEMBL | Antagonist activity at human mineralocorticoid receptor assessed as inhibition of binding to coactivator peptide by NH Pro assay | B | 6.62 | pIC50 | 240 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4388-4392 [PMID:23777778] |
| ChEMBL | Displacement of [3H]-aldosterone from recombinant human mineralocorticoid receptor expressed in baculovirus infected insect cells incubated overnight by liquid scintillation counting analysis | B | 6.65 | pIC50 | 226 | nM | IC50 | J Med Chem (2022) 65: 8127-8143 [PMID:35652647] |
| ChEMBL | Antagonist activity at human wild-type mineralocorticoid receptor expressed in CHO-K1 cells assessed as inhibition of aldosterone-induced transcriptional activity incubated for 24 hrs in presence of 1 nM aldosterone by Steady-Glo reagent based reporter gene assay | B | 6.75 | pIC50 | 178 | nM | IC50 | J Med Chem (2022) 65: 8127-8143 [PMID:35652647] |
| ChEMBL | Antagonist activity at Gal4-fused mineralocorticoid receptor expressed in human HuH7 cells assessed as inhibition of aldosterone-induced receptor activation by luciferase reporter gene assay | F | 6.87 | pIC50 | 135 | nM | IC50 | J Med Chem (2010) 53: 4300-4304 [PMID:20408553] |
| ChEMBL | Antagonist activity at mineralocorticoid receptor (unknown origin) by Gal4-based cellular assay | B | 6.91 | pIC50 | 122 | nM | IC50 | J Med Chem (2014) 57: 4273-4288 [PMID:24738581] |
| ChEMBL | Antagonist activity at Gal4-tagged mineralocorticoid receptor expressed in human Huh7 cells by luciferase reporter gene assay | F | 6.91 | pIC50 | 122 | nM | IC50 | J Med Chem (2010) 53: 5979-6002 [PMID:20672822] |
| ChEMBL | Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assay | F | 6.91 | pIC50 | 122 | nM | IC50 | J Med Chem (2010) 53: 5970-5978 [PMID:20672820] |
| ChEMBL | Modulation activity at human mineralocorticoid receptor in human EA.hy926 cells assessed as blocking of nuclear translocation of mineralocorticoid receptor in presence of aldosterone by receptor translocation assay | B | 7.2 | pIC50 | 63.1 | nM | IC50 | J Med Chem (2019) 62: 1385-1406 [PMID:30596500] |
| ChEMBL | Modulation activity at human mineralocorticoid receptor in human EA.hy926 cells assessed as induction of nuclear translocation of mineralocorticoid receptor in absence of aldosterone by receptor translocation assay | B | 7 | pEC50 | 100 | nM | EC50 | J Med Chem (2019) 62: 1385-1406 [PMID:30596500] |
| Mineralocorticoid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3507] [GtoPdb: 626] [UniProtKB: P22199] | ||||||||
| ChEMBL | Displacement of [3H]-aldosterone from rat mineralocorticoid receptor incubated overnight by liquid scintillation counting analysis | B | 7.35 | pKi | 44.4 | nM | Ki | J Med Chem (2022) 65: 8127-8143 [PMID:35652647] |
| ChEMBL | Antagonist activity at gal4-fused rat mineralocorticoid receptor LBD in expressed in human U2OS cells by luciferase reporter gene assay | B | 7.4 | pIC50 | 39.81 | nM | IC50 | J Med Chem (2019) 62: 1385-1406 [PMID:30596500] |
| Progesterone receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL208] [GtoPdb: 627] [UniProtKB: P06401] | ||||||||
| ChEMBL | Binding affinity to recombinant human progesterone receptor LBD by fluormone PL red-fluorescence polarization assay | B | 4.7 | pKi | 19952.62 | nM | Ki | J Med Chem (2019) 62: 1385-1406 [PMID:30596500] |
| ChEMBL | Antagonist activity at progesterone receptor beta (unknown origin) by NH Pro assay | B | 4.7 | pIC50 | >20000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4388-4392 [PMID:23777778] |
| ChEMBL | Antagonist activity at progesterone receptor | F | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 5979-6002 [PMID:20672822] |
| ChEMBL | Displacement of [3H]progesterone from PR | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2011) 54: 8616-8631 [PMID:22074142] |
| ChEMBL | Displacement of [[3H]-Progesterone from progesterone receptor (unknown origin) expressed in 293 cells after 16 hrs by scintillation counting | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem (2014) 22: 5428-5445 [PMID:25187277] |
| ChEMBL | Displacement of [3H]-Dexamethasone from glucocorticoid receptor (unknown origin) expressed in 293 cells after 16 hrs by scintillation counting | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem (2014) 22: 5428-5445 [PMID:25187277] |
| ChEMBL | Agonist activity at progesterone receptor beta (unknown origin) by NH Pro assay | B | 4.7 | pEC50 | >20000 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 4388-4392 [PMID:23777778] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
