triamcinolone acetonide [Ligand Id: 2867] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1504 (Adcortyl, Adcortyl in orabase, Allernaze, Aristocort, Aristocort a, Aristogel, Audicort, Aureocort, Azmacort, Flutex, FX-006, FX006, Gppe ear dps cap, Gppe ear oint, Kenacort, Kenacourt, Kenalog, Kenalog-10, Kenalog-40, Kenalog-80, Kenalog-h, Kenalog in orabase, Nasacort, Nasacort allergy 24 hour, Nasacort aq, Nasacort hfa, NSC-21916, Nystadermal, Oracort, Oralone, Pevaryl t.c., Remiderm, Remotic, Silderm, Triacet, Triacort, Tri-adcortyl, Triamcinolone acetonide, Triamcinolone Acetonide, Triamcinolone acetonide in absorbase, Triatex, Triderm, Triesence, Tri-Nasal, Trivaris, Trymex, Vetalog, Xipere, Zilretta)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Glucocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150]
ChEMBL DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) B 8.7 pKi 2.01 nM Ki DrugMatrix in vitro pharmacology data
GtoPdb - - 8.2 pIC50 - - - Endocrinology (1981) 108: 1414-9 [PMID:7472274];
Brain Res (1995) 685: 105-16 [PMID:7583234]
ChEMBL DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) B 8.36 pIC50 4.41 nM IC50 DrugMatrix in vitro pharmacology data
Progesterone receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1909044] [UniProtKB: Q690N0]
ChEMBL DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) B 7.64 pKi 23 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) B 6.75 pIC50 179 nM IC50 DrugMatrix in vitro pharmacology data

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]