androstenedione [Ligand Id: 2860] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL274826 (Androstenedione) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Alpha-synuclein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6152] [UniProtKB: P37840] | ||||||||
| ChEMBL | Inhibition of alpha-synuclein aggregation (unknown origin) incubated for 8 days by thioflavin S based fluorescence assay | B | 4.07 | pIC50 | 85900 | nM | IC50 | Eur J Med Chem (2019) 167: 10-36 [PMID:30743095] |
| Androgen receptor/Androgen Receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207] | ||||||||
| ChEMBL | Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881) | B | 5.89 | pIC50 | 1288.25 | nM | IC50 | J Med Chem (2005) 48: 5666-5674 [PMID:16134935] |
| ChEMBL | In vitro antagonist activity against rat prostatic androgen receptor (AR) | F | 7.19 | pIC50 | 64 | nM | IC50 | J Med Chem (1986) 29: 2298-2315 [PMID:3783591] |
| GtoPdb | - | - | 8.56 | pIC50 | - | - | - | Chem Res Toxicol (2003) 16: 1338-58 [PMID:14565775] |
| Corticosteroid binding globulin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2421] [UniProtKB: P08185] | ||||||||
| ChEMBL | In silico binding affinity to human corticosteriod binding globulin | B | 4.76 | pKd | 4.76 | - | -Log Kdiss | J Med Chem (1997) 40: 3161-3172 [PMID:9379435] |
| ChEMBL | Binding affinity to human CBG receptor (corticosteroid-binding globulins) | B | 5.76 | pKi | 1737.8 | nM | Ki | J Med Chem (2004) 47: 2732-2742 [PMID:15139751] |
| CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] | ||||||||
| ChEMBL | Competitive inhibition of human aromatase extracted from placental microsomes after 5 mins by Dixon plot analysis in presence of [1beta-3H]AD | B | 7.46 | pKi | 35 | nM | Ki | Eur J Med Chem (2015) 105: 1-38 [PMID:26469743] |
| ChEMBL | Binding affinity for aromatase cytochrome P45019A1 by analysis of Dixon plot | B | 7.7 | pKi | 20 | nM | Ki | J Med Chem (1994) 37: 2198-2205 [PMID:8035427] |
| ChEMBL | In vitro competitive inhibitory activity was measured on Cytochrome P450 19A1 of human placental microsomes | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (1994) 37: 2198-2205 [PMID:8035427] |
| ChEMBL | Inhibition of aromatase | B | 6.59 | pIC50 | >=260 | nM | IC50 | Bioorg Med Chem (2012) 20: 2603-2613 [PMID:22444875] |
| Estradiol 17-beta-dehydrogenase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4234] [UniProtKB: P37058] | ||||||||
| ChEMBL | Inhibitory concentration against type-3 17-beta-HSD expressed in HEK293 cells | B | 6.12 | pIC50 | 758 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 2533-2536 [PMID:11086723] |
| ChEMBL | Ability to inhibit the Type-3 17-beta- hydroxysteroid dehydrogenase activity transfected in human embryonic kidney (HEK)-293 cells experiment 1 | B | 6.12 | pIC50 | 758 | nM | IC50 | J Med Chem (2002) 45: 640-653 [PMID:11806715] |
| ChEMBL | Inhibition of type-3 17 beta-hydroxysteroid dehydrogenase expressed in HEK293 cells at 37 degree C pH7.4 | B | 6.12 | pIC50 | 758 | nM | IC50 | J Med Chem (2005) 48: 5257-5268 [PMID:16078844] |
| ChEMBL | Ability to inhibit the Type-3 17-beta- hydroxysteroid dehydrogenase activity transfected in human embryonic kidney (HEK)-293 cells experiment 2 | B | 6.19 | pIC50 | 650 | nM | IC50 | J Med Chem (2002) 45: 640-653 [PMID:11806715] |
| ChEMBL | Ability to inhibit the Type-3 17-beta- hydroxysteroid dehydrogenase activity transfected in human embryonic kidney (HEK)-293 cells experiment 3 | B | 6.31 | pIC50 | 489 | nM | IC50 | J Med Chem (2002) 45: 640-653 [PMID:11806715] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | F | 5 | pIC50 | 10000 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| Testis-specific androgen-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3305] [UniProtKB: P04278] | ||||||||
| ChEMBL | Binding affinity towards human testosterone binding globulin. | B | 6.46 | pKd | 6.46 | - | -Log Kdiss | J Med Chem (1997) 40: 3161-3172 [PMID:9379435] |
| ChEMBL | Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin | B | 7.46 | pKd | 34.67 | nM | Kd | J Med Chem (2008) 51: 2047-2056 [PMID:18330978] |
| Testosterone 17-beta-dehydrogenase 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075158] [UniProtKB: O54939] | ||||||||
| ChEMBL | Inhibition of 17beta-HSD3 in rat testes microsomes using [14C]-4-androstene-3,17-dione as substrate after 2 hrs | B | 6.77 | pIC50 | 169 | nM | IC50 | Bioorg Med Chem (2015) 23: 5433-5451 [PMID:26277760] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
