mibolerone [Ligand Id: 2859] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL425863 (Cheque drops, Dihydrolone, Matenon, Mibolerona, Mibolerone, Mibolerone ciii, NSC-72260, U-10,997, U-10-997, U-10997) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Androgen receptor in Human [GtoPdb: 628] [UniProtKB: P10275] | ||||||||
| GtoPdb | - | - | 8.96 | pIC50 | 1.1 | nM | IC50 | J Clin Endocrinol Metab (2000) 85: 2253-9 [PMID:10852459] |
| Androgen receptor/Androgen Receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207] | ||||||||
| ChEMBL | Inhibition of [3H]mibolerone binding to cytosolic androgen receptor of rat ventral prostate | B | 9.12 | pKi | 0.76 | nM | Ki | J Med Chem (2005) 48: 917-925 [PMID:15715462] |
| ChEMBL | Binding affinity against rat prostate cytosolic Androgen receptor using [3H]mibolerone as radioligand | B | 9.12 | pKi | 0.75 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1045-1047 [PMID:11327585] |
| ChEMBL | Inhibitory constant against rat prostate cytosol androgen receptor using [3H]mibolerone | B | 9.12 | pKi | 0.75 | nM | Ki | J Med Chem (2000) 43: 3344-3347 [PMID:10966753] |
| ChEMBL | Inhibition of rat prostate cytosolic androgen receptor | B | 9.12 | pKi | 0.75 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 5285-5288 [PMID:15454212] |
| ChEMBL | Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881) | B | 8.78 | pIC50 | 1.66 | nM | IC50 | J Med Chem (2005) 48: 5666-5674 [PMID:16134935] |
| GtoPdb | - | - | 8.8 | pIC50 | - | - | - | Chem Res Toxicol (2003) 16: 1338-58 [PMID:14565775] |
| ChEMBL | Displacement of [3H]-MIB from rat prostate cytosolic androgen receptor by liquid scintillation counting method | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem (2017) 25: 1600-1607 [PMID:28174065] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
