ChEMBL ligand: CHEMBL193836 (GSK4716)
Alpha trans-inducing protein (VP16) in Herpes simplex virus (type 1 / strain 17) [ChEMBL: CHEMBL4218] [UniProtKB: P06492] There should be some charts here, you may need to enable JavaScript!
Estrogen-related receptor-γ/Estrogen-related receptor gamma in Human [ChEMBL: CHEMBL4245] [GtoPdb: 624] [UniProtKB: P62508] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Alpha trans-inducing protein (VP16) in Herpes simplex virus (type 1 / strain 17) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4218] [UniProtKB: P06492]
ChEMBL	Agonist activity at Herpes simplex virus Gal4 fused VP16-LBD expressed in HEK293T cells after 20 hrs by UAS-luciferase reporter gene assay	B	6.56	pEC50	272.6	nM	EC50	Bioorg Med Chem Lett (2018) 28: 1313-1319 [PMID:29548571]
Estrogen-related receptor-γ/Estrogen-related receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4245] [GtoPdb: 624] [UniProtKB: P62508]
ChEMBL	Binding affinity to ERRgamma (unknown origin) at 20 degC by isothermal titration calorimetry	B	5.3	pKd	5000	nM	Kd	Bioorg Med Chem (2015) 23: 3751-3760 [PMID:25910584]
ChEMBL	Inhibition of [3H]4-OHT binding to Estrogen-Related Receptor gamma	B	5.7	pIC50	2000	nM	IC50	J Med Chem (2005) 48: 3107-3109 [PMID:15857113]
GtoPdb	-	-	5.7	pIC50	-	-	-	J Med Chem (2005) 48: 3107-9 [PMID:15857113]
ChEMBL	Agonist activity at Gal4 fused ERRgamma-LBD (unknown origin) expressed in HEK293T cells after 20 hrs by UAS-luciferase reporter gene assay	B	5.72	pEC50	1899	nM	EC50	Bioorg Med Chem Lett (2018) 28: 1313-1319 [PMID:29548571]
ChEMBL	Estrogen-Related Receptor gamma activity in FRET assay	F	5.89	pEC50	1300	nM	EC50	J Med Chem (2005) 48: 3107-3109 [PMID:15857113]
ChEMBL	Agonist activity at human N-terminal alphaHis-SUMO-tagged ERRgamma-LBD (229 to 458 residues) expressed in Escherichia coli BL21 gold (DE3) cells assessed as decrease in RIP140 peptide recruitment after 2 hrs by TR-FRET assay	B	6.22	pEC50	600	nM	EC50	Bioorg Med Chem Lett (2018) 28: 1313-1319 [PMID:29548571]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]