ChEMBL ligand: CHEMBL69091
Retinoic acid receptor-α/Retinoic acid receptor alpha in Human [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276] There should be some charts here, you may need to enable JavaScript!
Retinoic acid receptor-β/Retinoic acid receptor beta in Human [ChEMBL: CHEMBL2008] [GtoPdb: 591] [UniProtKB: P10826] There should be some charts here, you may need to enable JavaScript!
Retinoic acid receptor-γ/Retinoic acid receptor gamma in Human [ChEMBL: CHEMBL2003] [GtoPdb: 592] [UniProtKB: P13631] There should be some charts here, you may need to enable JavaScript!
Retinoid X receptor-α/Retinoid X receptor alpha in Human [ChEMBL: CHEMBL2061] [GtoPdb: 610] [UniProtKB: P19793] There should be some charts here, you may need to enable JavaScript!
Retinoid X receptor-β/Retinoid X receptor beta in Human [ChEMBL: CHEMBL1870] [GtoPdb: 611] [UniProtKB: P28702] Retinoid X receptor-β in Mouse [GtoPdb: 611] [UniProtKB: P28704] There should be some charts here, you may need to enable JavaScript!
Retinoid X receptor-γ/Retinoid X receptor gamma in Human [ChEMBL: CHEMBL2004] [GtoPdb: 612] [UniProtKB: P48443] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Retinoic acid receptor-α/Retinoic acid receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276]
ChEMBL	Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]RA as a radioligand in baculovirus expressed receptor	B	5.02	pKd	9530	nM	Kd	Bioorg Med Chem Lett (1996) 6: 213-218
ChEMBL	Inhibition of [3H]ATRA binding to baculovirus expressed retinoic acid receptor RAR-alpha	B	5.02	pKd	9500	nM	Kd	J Med Chem (2001) 44: 2298-2303 [PMID:11428923]
ChEMBL	Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]RA as a radioligand in baculovirus expressed receptor	B	6.25	pKd	556	nM	Kd	Bioorg Med Chem Lett (1996) 6: 213-218
ChEMBL	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor alpha using transactivation assay	B	6	pEC50	>1000	nM	EC50	Bioorg Med Chem Lett (1996) 6: 213-218
ChEMBL	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor alpha using transactivation assay	B	6	pEC50	>1000	nM	EC50	Bioorg Med Chem Lett (1996) 6: 213-218
Retinoic acid receptor-β/Retinoic acid receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2008] [GtoPdb: 591] [UniProtKB: P10826]
ChEMBL	Inhibition of [3H]ATRA binding to baculovirus expressed retinoic acid receptor RAR-beta	B	4.69	pKd	20500	nM	Kd	J Med Chem (2001) 44: 2298-2303 [PMID:11428923]
ChEMBL	Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]RA as a radioligand in baculovirus expressed receptor	B	4.69	pKd	20472	nM	Kd	Bioorg Med Chem Lett (1996) 6: 213-218
ChEMBL	Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]RA as a radioligand in baculovirus expressed receptor	B	6	pKd	>1000	nM	Kd	Bioorg Med Chem Lett (1996) 6: 213-218
ChEMBL	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor beta using transactivation assay	B	6	pEC50	>1000	nM	EC50	Bioorg Med Chem Lett (1996) 6: 213-218
ChEMBL	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor beta using transactivation assay	B	6.47	pEC50	340	nM	EC50	Bioorg Med Chem Lett (1996) 6: 213-218
Retinoic acid receptor-γ/Retinoic acid receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2003] [GtoPdb: 592] [UniProtKB: P13631]
ChEMBL	Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]RA as a radioligand in baculovirus expressed receptor	B	4.8	pKd	15942	nM	Kd	Bioorg Med Chem Lett (1996) 6: 213-218
ChEMBL	Inhibition of [3H]ATRA binding to baculovirus expressed retinoic acid receptor RAR-gamma	B	4.8	pKd	15900	nM	Kd	J Med Chem (2001) 44: 2298-2303 [PMID:11428923]
ChEMBL	Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]RA as a radioligand in baculovirus expressed receptor	B	6	pKd	>1000	nM	Kd	Bioorg Med Chem Lett (1996) 6: 213-218
ChEMBL	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor gamma using transactivation assay	B	6	pEC50	>1000	nM	EC50	Bioorg Med Chem Lett (1996) 6: 213-218
ChEMBL	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor gamma using transactivation assay	B	6.7	pEC50	200	nM	EC50	Bioorg Med Chem Lett (1996) 6: 213-218
Retinoid X receptor-α/Retinoid X receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2061] [GtoPdb: 610] [UniProtKB: P19793]
ChEMBL	Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]-9-cis-RA as a radioligand in baculovirus expressed receptor	B	6	pKd	>1000	nM	Kd	Bioorg Med Chem Lett (1996) 6: 213-218
ChEMBL	Inhibition of [3H]9-cis-retinoic acid binding to baculovirus expressed retinoic acid receptor RXR-alpha	B	8.82	pKd	1.5	nM	Kd	J Med Chem (2001) 44: 2298-2303 [PMID:11428923]
ChEMBL	Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]-9-cis-RA as a radioligand in baculovirus expressed receptor	B	8.82	pKd	1.5	nM	Kd	Bioorg Med Chem Lett (1996) 6: 213-218
GtoPdb	-	-	9.4	pIC50	-	-	-	J Med Chem (2001) 44: 2298-303 [PMID:11428923]
ChEMBL	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor alpha using transactivation assay	B	6	pEC50	>1000	nM	EC50	Bioorg Med Chem Lett (1996) 6: 213-218
ChEMBL	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor alpha using transactivation assay	B	8.82	pEC50	1.5	nM	EC50	Bioorg Med Chem Lett (1996) 6: 213-218
Retinoid X receptor-β/Retinoid X receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1870] [GtoPdb: 611] [UniProtKB: P28702]
ChEMBL	Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]9-cis-RA as a radioligand in baculovirus expressed receptor	B	6	pKd	>1000	nM	Kd	Bioorg Med Chem Lett (1996) 6: 213-218
ChEMBL	Inhibition of [3H]9-cis-retinoic acid binding to baculovirus expressed retinoic acid receptor RXR-beta	B	8.6	pKd	2.5	nM	Kd	J Med Chem (2001) 44: 2298-2303 [PMID:11428923]
ChEMBL	Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]9-cis-RA as a radioligand in baculovirus expressed receptor	B	8.6	pKd	2.5	nM	Kd	Bioorg Med Chem Lett (1996) 6: 213-218
ChEMBL	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor beta using transactivation assay	B	6	pEC50	>1000	nM	EC50	Bioorg Med Chem Lett (1996) 6: 213-218
ChEMBL	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor beta using transactivation assay	B	8.7	pEC50	2	nM	EC50	Bioorg Med Chem Lett (1996) 6: 213-218
Retinoid X receptor-β in Mouse [GtoPdb: 611] [UniProtKB: P28704]
GtoPdb	-	-	8.44	pIC50	-	-	-	J Med Chem (2001) 44: 2298-303 [PMID:11428923]
Retinoid X receptor-γ/Retinoid X receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2004] [GtoPdb: 612] [UniProtKB: P48443]
ChEMBL	Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]9-cis-RA as a radioligand in baculovirus expressed receptor	B	6	pKd	>1000	nM	Kd	Bioorg Med Chem Lett (1996) 6: 213-218
ChEMBL	Inhibition of [3H]9-cis-retinoic acid binding to baculovirus expressed retinoic acid receptor RXR-gamma	B	8.74	pKd	1.8	nM	Kd	J Med Chem (2001) 44: 2298-2303 [PMID:11428923]
ChEMBL	Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]9-cis-RA as a radioligand in baculovirus expressed receptor	B	8.74	pKd	1.8	nM	Kd	Bioorg Med Chem Lett (1996) 6: 213-218
ChEMBL	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor gamma using transactivation assay	B	6	pEC50	>1000	nM	EC50	Bioorg Med Chem Lett (1996) 6: 213-218
ChEMBL	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor gamma using transactivation assay	B	9	pEC50	1	nM	EC50	Bioorg Med Chem Lett (1996) 6: 213-218

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]