SB 216641 [Ligand Id: 28] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL20963
  • 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
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  • 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
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  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
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  • 5-HT1A receptor in Human [GtoPdb: 1] [UniProtKB: P08908]
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  • 5-HT2B receptor in Human [GtoPdb: 7] [UniProtKB: P41595]
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  • 5-HT2C receptor in Human [GtoPdb: 8] [UniProtKB: P28335]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
GtoPdb - - 9 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (1997) 356: 312-20 [PMID:9303567]
ChEMBL Binding affinity for human 5-hydroxytryptamine 1B receptor B 9 pKi 1 nM Ki J Med Chem (1998) 41: 1218-1235 [PMID:9548813]
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
ChEMBL Binding affinity for human 5-hydroxytryptamine 1D receptor B 7.5 pKi 31.62 nM Ki J Med Chem (1998) 41: 1218-1235 [PMID:9548813]
GtoPdb - - 7.6 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (1997) 356: 312-20 [PMID:9303567]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
ChEMBL Binding affinity for human 5-hydroxytryptamine 2A receptor B 7.3 pKi 50.12 nM Ki J Med Chem (1998) 41: 1218-1235 [PMID:9548813]
GtoPdb - - 7.3 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (1997) 356: 312-20 [PMID:9303567]
5-HT1A receptor in Human [GtoPdb: 1] [UniProtKB: P08908]
GtoPdb - - 6.3 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (1997) 356: 312-20 [PMID:9303567]
5-HT2B receptor in Human [GtoPdb: 7] [UniProtKB: P41595]
GtoPdb - - 5.8 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (1997) 356: 312-20 [PMID:9303567]
5-HT2C receptor in Human [GtoPdb: 8] [UniProtKB: P28335]
GtoPdb - - 6.8 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (1997) 356: 312-20 [PMID:9303567]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]