acetyl-podocarpic dimer [Ligand Id: 2753] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL506838 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Liver X receptor-α/Oxysterols receptor LXR-alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2808] [GtoPdb: 602] [UniProtKB: Q13133] | ||||||||
| GtoPdb | - | - | 9 | pEC50 | - | - | - | J Biol Chem (2002) 277: 10021-7 [PMID:11790770] |
| ChEMBL | Agonist activity at human recombinant LXRalpha expressed in Escherichia coli BL21 cells assessed as association of recombinant SRC1 to LXRalpha ligand binding domain by HTRF assay | B | 9 | pEC50 | 1 | nM | EC50 | J Nat Prod (2005) 68: 1247-1252 [PMID:16124770] |
| ChEMBL | Affinity On-target Cellular interaction: (Reporter gene assay (HEK293T cells)) EUB0001167a NR1H3 | F | 9 | pEC50 | 1 | nM | EC50 | Affinity On-target Cellular Literature for EUbOPEN Chemogenomic Library |
| Liver X receptor-β/Oxysterols receptor LXR-beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4093] [GtoPdb: 601] [UniProtKB: P55055] | ||||||||
| ChEMBL | Agonist activity at human recombinant LXRbeta expressed in Escherichia coli BL21 cells assessed as association of recombinant SRC1 to LXRbeta ligand binding domain by HTRF assay | B | 8.52 | pEC50 | <3 | nM | EC50 | J Nat Prod (2005) 68: 1247-1252 [PMID:16124770] |
| GtoPdb | - | - | 9 | pEC50 | - | - | - | J Biol Chem (2002) 277: 10021-7 [PMID:11790770] |
| ChEMBL | Affinity On-target Cellular interaction: (Reporter gene assay (HEK293T cells)) EUB0001167a NR1H2 | F | 9 | pEC50 | 1 | nM | EC50 | Affinity On-target Cellular Literature for EUbOPEN Chemogenomic Library |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
