ChEMBL ligand: CHEMBL434302 (24(S), 25-Epoxycholesterol, 24(S),25-Epoxycholesterol)
Liver X receptor-α/LXR-alpha in Human [ChEMBL: CHEMBL2808] [GtoPdb: 602] [UniProtKB: Q13133] There should be some charts here, you may need to enable JavaScript!
Liver X receptor-β/LXR-beta in Human [ChEMBL: CHEMBL4093] [GtoPdb: 601] [UniProtKB: P55055] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Liver X receptor-α/LXR-alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2808] [GtoPdb: 602] [UniProtKB: Q13133]
ChEMBL	Binding affinity to human LXRalpha	B	4.7	pEC50	>20000	nM	EC50	J Med Chem (2016) 59: 3264-3271 [PMID:26990539]
ChEMBL	Effective concentration in LXR alpha-Gal4 receptor gene assay	B	5.52	pEC50	3000	nM	EC50	J Med Chem (2002) 45: 1963-1966 [PMID:11985463]
ChEMBL	Activity against LXR alpha transiently transfected in HEK293 cells	B	6.3	pEC50	500	nM	EC50	Bioorg Med Chem Lett (2006) 16: 1638-1642 [PMID:16386417]
ChEMBL	Concentration required for half maximal activity was calculated in human nuclear oxysterol receptor liver X receptor-alpha in LiSA.	B	6.34	pEC50	460	nM	EC50	J Med Chem (2001) 44: 886-897 [PMID:11300870]
GtoPdb	-	-	6.5	pEC50	-	-	-	Proc Natl Acad Sci USA (1999) 96: 266-71 [PMID:9874807]; J Biol Chem (1997) 272: 3137-40 [PMID:9013544]; Nat Chem Biol (2013) 9: 126-33 [PMID:23292650]
ChEMBL	Agonist activity at LXRalpha ligand binding domain by FRET based SRC1 recruitment assay	B	6.55	pEC50	280	nM	EC50	Bioorg Med Chem Lett (2009) 19: 2009-2012 [PMID:19264481]
ChEMBL	Agonist activity at human LXRalpha coexpressed in African green monkey CV1 cells by Gal4 responsive reporter gene assay	B	6.93	pEC50	117	nM	EC50	J Med Chem (2016) 59: 3264-3271 [PMID:26990539]
ChEMBL	Ligand-dependent recruitment of steroid receptor co-activator 1 (SRC1) to Liver X receptor-alpha	B	7.02	pEC50	95	nM	EC50	J Med Chem (2002) 45: 1963-1966 [PMID:11985463]
Liver X receptor-β/LXR-beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4093] [GtoPdb: 601] [UniProtKB: P55055]
ChEMBL	Binding to human LXRbeta	B	4.7	pEC50	>20000	nM	EC50	J Med Chem (2016) 59: 3264-3271 [PMID:26990539]
ChEMBL	Agonist activity at human LXRbeta expressed in human SH-SY5Y cells co-transfected with Gal4-LBD after 24 hrs by luciferase reporter gene assay	F	6.4	pEC50	400	nM	EC50	Bioorg Med Chem Lett (2009) 19: 2009-2012 [PMID:19264481]
ChEMBL	Agonist activity at LXRbeta ligand binding domain by FRET based SRC1 recruitment assay	B	6.54	pEC50	286	nM	EC50	Bioorg Med Chem Lett (2009) 19: 2009-2012 [PMID:19264481]
ChEMBL	Agonist activity at human LXRbeta coexpressed in African green monkey CV1 cells by Gal4 responsive reporter gene assay	B	6.77	pEC50	168	nM	EC50	J Med Chem (2016) 59: 3264-3271 [PMID:26990539]
GtoPdb	-	-	7.04	pEC50	-	-	-	J Biol Chem (1997) 272: 3137-40 [PMID:9013544]; Nat Chem Biol (2013) 9: 126-33 [PMID:23292650]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]