ChEMBL ligand: CHEMBL46071 (Ro-63-0563)
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406] 5-HT6 receptor in Rat [GtoPdb: 11] [UniProtKB: P31388] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
ChEMBL	Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in HEK293 cells	B	6.29	pKi	512	nM	Ki	Bioorg Med Chem Lett (2008) 18: 738-743 [PMID:18053713]
ChEMBL	Binding affinity to 5HT6 receptor	B	7.8	pKi	15.85	nM	Ki	Bioorg Med Chem Lett (2011) 21: 698-703 [PMID:21190848]
ChEMBL	Binding affinity for human 5-hydroxytryptamine 6 receptor	B	7.8	pKi	15.85	nM	Ki	J Med Chem (2005) 48: 4216-4219 [PMID:15974573]
ChEMBL	Inhibition of [3H]LSD binding to human 5-hydroxytryptamine 6 receptor expressed in HEK293 cells	B	7.83	pKi	14.8	nM	Ki	J Med Chem (2005) 48: 1781-1795 [PMID:15771424]
ChEMBL	Displacement of [3H]LSD from human 5-hydroxytryptamine 6 receptor expressed in HEK 293 cells	B	7.9	pKi	12.6	nM	Ki	Bioorg Med Chem Lett (2000) 10: 1719-1721 [PMID:10937732]
ChEMBL	Binding affinity against human cloned 5-hydroxytryptamine 6 receptor in HeLa cells using [3H]LSD	B	7.9	pKi	12.59	nM	Ki	J Med Chem (1999) 42: 202-205 [PMID:9925723]
ChEMBL	Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 1 hr by scintillation spectroscopic analysis	B	7.91	pKi	12.3	nM	Ki	J Med Chem (2014) 57: 5823-5828 [PMID:24878269]
ChEMBL	Binding affinity towards human 5-hydroxytryptamine 6 receptor	B	7.92	pKi	12	nM	Ki	J Med Chem (2003) 46: 2795-2812 [PMID:12825922]
ChEMBL	Displacement of [3H]LSD from human 5HT6 receptor expressed in HeLa cells	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2009) 19: 3214-3216 [PMID:19433358]
ChEMBL	Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 1 hr by scintillation spectroscopic analysis	B	7.92	pKi	12	nM	Ki	J Med Chem (2014) 57: 5823-5828 [PMID:24878269]
ChEMBL	Antagonist activity at human recombinant 5HT6 receptor expressed in CHO cells	B	7.92	pKi	12	nM	Ki	J Med Chem (2014) 57: 7160-7181 [PMID:24850589]
GtoPdb	-	-	8.4	pKi	3.98	nM	Ki	Mol Pharmacol (1998) 54: 577-583 [PMID:9730917]; Br J Pharmacol (1998) 124: 556-62 [PMID:9647481]
5-HT6 receptor in Rat [GtoPdb: 11] [UniProtKB: P31388]
GtoPdb	-	-	8	pKi	-	-	-	Mol Pharmacol (1998) 54: 577-583 [PMID:9730917]; Br J Pharmacol (1998) 124: 556-62 [PMID:9647481]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]