GW2331 [Ligand Id: 2680] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL248906 (GW2331) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869] | ||||||||
| ChEMBL | Inhibition of PPARalpha | B | 6.13 | pIC50 | 740 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 1939-1944 [PMID:18291645] |
| ChEMBL | Inhibition of human Peroxisome proliferator activated receptor alpha | B | 6.27 | pIC50 | 538 | nM | IC50 | J Med Chem (2005) 48: 2248-2250 [PMID:15771468] |
| ChEMBL | Displacement of fluorescein labeled ligand from PPARalpha receptor by fluorescence polarization assay | B | 6.46 | pIC50 | 348 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 2312-2316 [PMID:17292606] |
| ChEMBL | Agonist activity at PPARalpha receptor expressed in HEK293 cells by GAL4 transactivation assay | F | 7.15 | pEC50 | 71 | nM | EC50 | Bioorg Med Chem Lett (2007) 17: 2312-2316 [PMID:17292606] |
| ChEMBL | Agonist activity at PPARalpha in HEK293 cells by GAL4 transactivation assay | F | 7.35 | pEC50 | 45 | nM | EC50 | Bioorg Med Chem Lett (2008) 18: 1939-1944 [PMID:18291645] |
| ChEMBL | Effective concentration against human Peroxisome proliferator activated receptor alpha | B | 7.7 | pEC50 | <20 | nM | EC50 | J Med Chem (2005) 48: 2248-2250 [PMID:15771468] |
| Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] | ||||||||
| ChEMBL | Displacement of fluorescein labeled ligand from PPARgamma receptor by fluorescence polarization assay | B | 6.17 | pIC50 | 670 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 2312-2316 [PMID:17292606] |
| ChEMBL | Inhibition of PPARgamma | B | 6.22 | pIC50 | 600 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 1939-1944 [PMID:18291645] |
| ChEMBL | Inhibition of human Peroxisome proliferator activated receptor gamma | B | 6.5 | pIC50 | 316 | nM | IC50 | J Med Chem (2005) 48: 2248-2250 [PMID:15771468] |
| ChEMBL | Effective concentration against human Peroxisome proliferator activated receptor gamma | B | 6.37 | pEC50 | 425 | nM | EC50 | J Med Chem (2005) 48: 2248-2250 [PMID:15771468] |
| ChEMBL | Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assay | F | 6.6 | pEC50 | 249 | nM | EC50 | Bioorg Med Chem Lett (2007) 17: 2312-2316 [PMID:17292606] |
| ChEMBL | Agonist activity at PPARgamma in HEK293 cells by GAL4 transactivation assay | F | 6.61 | pEC50 | 243 | nM | EC50 | Bioorg Med Chem Lett (2008) 18: 1939-1944 [PMID:18291645] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
