NS-220 [Ligand Id: 2678] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL270960 (NS-220) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869] | ||||||||
| ChEMBL | Agonist activity at human PPARalpha ligand binding domain expressed in human HepG2 cells co-transfected with PPRE3-TK-luc assessed as induction of beta-galactosidase activity by transactivation assay | B | 5.15 | pEC50 | 7000 | nM | EC50 | Bioorg Med Chem Lett (2008) 18: 5586-5590 [PMID:18805005] |
| GtoPdb | - | - | 6.73 | pEC50 | - | - | - | J Pharmacol Exp Ther (2004) 309: 970-7 [PMID:14982965] |
| ChEMBL | Agonist activity at human PPARalpha transactivation expressed in human HePG2 cells | F | 7.28 | pEC50 | 52 | nM | EC50 | Bioorg Med Chem Lett (2008) 18: 6471-6475 [PMID:18976908] |
| ChEMBL | Agonist activity at human PPARalpha expressed in CV1 cells by transactivation assay | F | 8 | pEC50 | 10 | nM | EC50 | Bioorg Med Chem (2008) 16: 981-994 [PMID:17964792] |
| Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2128] [GtoPdb: 593] [UniProtKB: P23204] | ||||||||
| ChEMBL | Agonist activity at mouse PPARalpha expressed in CV1 cells by transactivation assay | F | 7.52 | pEC50 | 30 | nM | EC50 | Bioorg Med Chem (2008) 16: 981-994 [PMID:17964792] |
| Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181] | ||||||||
| ChEMBL | Agonist activity at human PPARdelta expressed in CV1 cells by transactivation assay | F | 4 | pEC50 | >100000 | nM | EC50 | Bioorg Med Chem (2008) 16: 981-994 [PMID:17964792] |
| Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] | ||||||||
| ChEMBL | Agonist activity at human PPARgamma expressed in CV1 cells by transactivation assay | F | 5.02 | pEC50 | 9600 | nM | EC50 | Bioorg Med Chem (2008) 16: 981-994 [PMID:17964792] |
| ChEMBL | Agonist activity at human PPARgamma ligand binding domain expressed in human HepG2 cells co-transfected with PPRE3-TK-luc assessed as induction of beta-galactosidase activity by transactivation assay | B | 5.15 | pEC50 | 7000 | nM | EC50 | Bioorg Med Chem Lett (2008) 18: 5586-5590 [PMID:18805005] |
| ChEMBL | Agonist activity at human PPARgamma transactivation expressed in human HePG2 cells | F | 5.16 | pEC50 | 6850 | nM | EC50 | Bioorg Med Chem Lett (2008) 18: 6471-6475 [PMID:18976908] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
