AD-5061 [Ligand Id: 2663] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL59132 (AD-7057) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869] | ||||||||
| ChEMBL | Binding affinity towards human peroxidase proliferator activated receptor alpha (hPPARalpha) | B | 5.39 | pIC50 | 4086 | nM | IC50 | J Med Chem (2001) 44: 2061-2064 [PMID:11405642] |
| GtoPdb | - | - | 5.6 | pIC50 | - | - | - |
Biochem Biophys Res Commun (2000) 278: 704-11 [PMID:11095972]; Eur J Pharmacol (2004) 495: 17-26 [PMID:15219816] |
| ChEMBL | Binding affinity at human PPAR alpha | B | 6.11 | pEC50 | 771 | nM | EC50 | J Med Chem (2001) 44: 2061-2064 [PMID:11405642] |
| Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] | ||||||||
| ChEMBL | In vitro binding to peroxisome proliferator activated receptor gamma (PPAR gamma) using [3H]-BRL 49653 as radioligand in scintillation proximity assay (SPA) | B | 8.37 | pKi | 4.27 | nM | Ki | J Med Chem (1998) 41: 5020-5036 [PMID:9836620] |
| GtoPdb | - | - | 7.7 | pIC50 | - | - | - |
Biochem Biophys Res Commun (2000) 278: 704-11 [PMID:11095972]; Eur J Pharmacol (2004) 495: 17-26 [PMID:15219816] |
| ChEMBL | Binding affinity at human peroxidase proliferator activated receptor gamma (hPPARgamma) | B | 7.85 | pIC50 | 14 | nM | IC50 | J Med Chem (2001) 44: 2061-2064 [PMID:11405642] |
| ChEMBL | Binding affinity at human PPAR gamma | B | 8.1 | pEC50 | 8 | nM | EC50 | J Med Chem (2001) 44: 2061-2064 [PMID:11405642] |
| ChEMBL | Activation of peroxisome proliferator activated receptor gamma measured by induction of 50% of maximum alkaline phosphatase activity, transfection assay in CV-1 cells | F | 8.5 | pEC50 | 3.16 | nM | EC50 | J Med Chem (1998) 41: 5020-5036 [PMID:9836620] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
