LY-518674 [Ligand Id: 2658] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL424133 (KB-68984, Ly-518674, LY518674, LY-674) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869] | ||||||||
| GtoPdb | - | - | 7.6 | pIC50 | - | - | - | J Med Chem (2003) 46: 5121-4 [PMID:14613314] |
| ChEMBL | Inhibitory activity against human Peroxisome proliferator activated receptor alpha | B | 7.62 | pIC50 | 24 | nM | IC50 | J Med Chem (2003) 46: 5121-5124 [PMID:14613314] |
| ChEMBL | Agonist activity at PPARalpha | F | 7.62 | pIC50 | 23.99 | nM | IC50 | Bioorg Med Chem (2012) 20: 3523-3532 [PMID:22564380] |
| ChEMBL | Cotransfection activity against human Peroxisome proliferator activated receptor alpha | F | 7.38 | pEC50 | 42 | nM | EC50 | J Med Chem (2003) 46: 5121-5124 [PMID:14613314] |
| ChEMBL | Agonist activity at human PPAR-alpha | B | 7.38 | pEC50 | 42 | nM | EC50 | Bioorg Med Chem Lett (2014) 24: 2267-2272 [PMID:24745969] |
| ChEMBL | Agonist activity at human PPARalpha | B | 7.38 | pEC50 | 42 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 503-508 [PMID:30594433] |
| Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181] | ||||||||
| ChEMBL | Agonist activity at PPARdelta | F | 5.42 | pIC50 | 3801.89 | nM | IC50 | Bioorg Med Chem (2012) 20: 3523-3532 [PMID:22564380] |
| ChEMBL | Inhibitory activity of compound against the binding of human Peroxisome proliferator activated receptor delta was determined | B | 5.42 | pIC50 | 3800 | nM | IC50 | J Med Chem (2003) 46: 5121-5124 [PMID:14613314] |
| Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] | ||||||||
| ChEMBL | Agonist activity at PPARgamma | F | 5.19 | pIC50 | 6501.3 | nM | IC50 | Bioorg Med Chem (2012) 20: 3523-3532 [PMID:22564380] |
| ChEMBL | Inhibitory activity of compound against the binding of human Peroxisome proliferator activated receptor gamma was determined | B | 5.19 | pIC50 | 6500 | nM | IC50 | J Med Chem (2003) 46: 5121-5124 [PMID:14613314] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
