LY-518674 [Ligand Id: 2658] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL424133 (KB-68984, Ly-518674, LY518674, LY-674) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869] | ||||||||
| GtoPdb | - | - | 7.6 | pIC50 | - | - | - | J Med Chem (2003) 46: 5121-4 [PMID:14613314] |
| ChEMBL | Inhibitory activity against human Peroxisome proliferator activated receptor alpha | B | 7.62 | pIC50 | 24 | nM | IC50 | J Med Chem (2003) 46: 5121-5124 [PMID:14613314] |
| ChEMBL | Agonist activity at PPARalpha | F | 7.62 | pIC50 | 23.99 | nM | IC50 | Bioorg Med Chem (2012) 20: 3523-3532 [PMID:22564380] |
| ChEMBL | Cotransfection activity against human Peroxisome proliferator activated receptor alpha | F | 7.38 | pEC50 | 42 | nM | EC50 | J Med Chem (2003) 46: 5121-5124 [PMID:14613314] |
| ChEMBL | Agonist activity at human PPAR-alpha | B | 7.38 | pEC50 | 42 | nM | EC50 | Bioorg Med Chem Lett (2014) 24: 2267-2272 [PMID:24745969] |
| ChEMBL | Agonist activity at human PPARalpha | B | 7.38 | pEC50 | 42 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 503-508 [PMID:30594433] |
| Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181] | ||||||||
| ChEMBL | Agonist activity at PPARdelta | F | 5.42 | pIC50 | 3801.89 | nM | IC50 | Bioorg Med Chem (2012) 20: 3523-3532 [PMID:22564380] |
| ChEMBL | Inhibitory activity of compound against the binding of human Peroxisome proliferator activated receptor delta was determined | B | 5.42 | pIC50 | 3800 | nM | IC50 | J Med Chem (2003) 46: 5121-5124 [PMID:14613314] |
| Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] | ||||||||
| ChEMBL | Agonist activity at PPARgamma | F | 5.19 | pIC50 | 6501.3 | nM | IC50 | Bioorg Med Chem (2012) 20: 3523-3532 [PMID:22564380] |
| ChEMBL | Inhibitory activity of compound against the binding of human Peroxisome proliferator activated receptor gamma was determined | B | 5.19 | pIC50 | 6500 | nM | IC50 | J Med Chem (2003) 46: 5121-5124 [PMID:14613314] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
