SB 699551 [Ligand Id: 264] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1181770 (SB-699551) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
| ChEMBL | Binding affinity to 5-HT1AR (unknown origin) assessed as inhibition constant | B | 5.7 | pKi | <2000 | nM | Ki | J Med Chem (2022) 65: 4201-4217 [PMID:35195401] |
| 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222] | ||||||||
| ChEMBL | Binding affinity to 5-HT1BR (unknown origin) assessed as inhibition constant | B | 5.7 | pKi | <2000 | nM | Ki | J Med Chem (2022) 65: 4201-4217 [PMID:35195401] |
| 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221] | ||||||||
| ChEMBL | Binding affinity to 5-HT1DR (unknown origin) assessed as inhibition constant | B | 5.7 | pKi | <2000 | nM | Ki | J Med Chem (2022) 65: 4201-4217 [PMID:35195401] |
| 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
| ChEMBL | Binding affinity to 5-HT2AR (unknown origin) assessed as inhibition constant | B | 5.7 | pKi | <2000 | nM | Ki | J Med Chem (2022) 65: 4201-4217 [PMID:35195401] |
| 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] | ||||||||
| ChEMBL | Binding affinity to 5-HT2BR (unknown origin) assessed as inhibition constant | B | 5.7 | pKi | <2000 | nM | Ki | J Med Chem (2022) 65: 4201-4217 [PMID:35195401] |
| 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
| ChEMBL | Binding affinity to 5-HT2CR (unknown origin) assessed as inhibition constant | B | 5.7 | pKi | <2000 | nM | Ki | J Med Chem (2022) 65: 4201-4217 [PMID:35195401] |
| 5-HT3A/Serotonin 3a (5-HT3a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098] | ||||||||
| ChEMBL | Binding affinity to 5-HT3 (unknown origin) assessed as inhibition constant | B | 5.7 | pKi | <2000 | nM | Ki | J Med Chem (2022) 65: 4201-4217 [PMID:35195401] |
| 5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3426] [GtoPdb: 10] [UniProtKB: P47898] | ||||||||
| ChEMBL | Binding affinity to human 5-HT5AR | B | 5.7 | pKi | <2000 | nM | Ki | J Med Chem (2022) 65: 4201-4217 [PMID:35195401] |
| GtoPdb | - | - | 8.2 | pKi | 6.3 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 4014-8 [PMID:16002289] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
