SB 699551 [Ligand Id: 264] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1181770 (SB-699551) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
| ChEMBL | Binding affinity to 5-HT1AR (unknown origin) assessed as inhibition constant | B | 5.7 | pKi | <2000 | nM | Ki | J Med Chem (2022) 65: 4201-4217 [PMID:35195401] |
| 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222] | ||||||||
| ChEMBL | Binding affinity to 5-HT1BR (unknown origin) assessed as inhibition constant | B | 5.7 | pKi | <2000 | nM | Ki | J Med Chem (2022) 65: 4201-4217 [PMID:35195401] |
| 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221] | ||||||||
| ChEMBL | Binding affinity to 5-HT1DR (unknown origin) assessed as inhibition constant | B | 5.7 | pKi | <2000 | nM | Ki | J Med Chem (2022) 65: 4201-4217 [PMID:35195401] |
| 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
| ChEMBL | Binding affinity to 5-HT2AR (unknown origin) assessed as inhibition constant | B | 5.7 | pKi | <2000 | nM | Ki | J Med Chem (2022) 65: 4201-4217 [PMID:35195401] |
| 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] | ||||||||
| ChEMBL | Binding affinity to 5-HT2BR (unknown origin) assessed as inhibition constant | B | 5.7 | pKi | <2000 | nM | Ki | J Med Chem (2022) 65: 4201-4217 [PMID:35195401] |
| 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
| ChEMBL | Binding affinity to 5-HT2CR (unknown origin) assessed as inhibition constant | B | 5.7 | pKi | <2000 | nM | Ki | J Med Chem (2022) 65: 4201-4217 [PMID:35195401] |
| 5-HT3A/Serotonin 3a (5-HT3a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098] | ||||||||
| ChEMBL | Binding affinity to 5-HT3 (unknown origin) assessed as inhibition constant | B | 5.7 | pKi | <2000 | nM | Ki | J Med Chem (2022) 65: 4201-4217 [PMID:35195401] |
| 5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3426] [GtoPdb: 10] [UniProtKB: P47898] | ||||||||
| ChEMBL | Binding affinity to human 5-HT5AR | B | 5.7 | pKi | <2000 | nM | Ki | J Med Chem (2022) 65: 4201-4217 [PMID:35195401] |
| GtoPdb | - | - | 8.2 | pKi | 6.3 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 4014-8 [PMID:16002289] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
